Author, as appears in the article.: Iglesias-Vázquez, L; Canals, J; Hernández-Martínez, C; Voltas, N; Arija, V
Department: Ciències Mèdiques Bàsiques Psicologia
URV's Author/s: Arija Val, Maria Victoria / Canals Sans, Josefa / Hernandez Martinez, Carmen / Iglesias Vazquez, Lucia / Voltas Moreso, Núria
Keywords: brain-development child behaviour consequences deficiency environment executive functioning hemoglobin iron supplementation nutrition pregnancy risk temperament Behavioural problems Child behaviour Executive functioning Iron supplementation Pregnancy Term-follow-up
Abstract: Prenatal iron supplementation improves children's health and cognitive performance, but few studies explore behavioural development. This study assessed the effects of adjusting prenatal iron supplementation to maternal iron stores during early pregnancy on children's behavioural problems. Randomized controlled trial conducted in Tarragona (Spain) involving 230 nonanaemic pregnant women and their children after a 4-year follow-up. Based on haemoglobin (Hb) levels before gestational week (GW) 12, women receive different iron doses: those with Hb = 110-130 g/L were randomized to receive 80 or 40 mg/day and those with Hb > 130 g/L were randomized to receive 20 or 40 mg/day. Maternal iron stores at GW12 were classified using serum ferritin (SF) as low (SF < 15 µg/L), normal (SF = 15-65 µg/L), and normal-high (SF > 65 µg/L). Children's behaviour was assessed by parents using the Child Behaviour Checklist for ages 1.5-5 years and the Behaviour Rating Inventory of Executive Function-Preschool Version, and by teachers using the Teacher's Report Form for ages 1.5-5 years. Multivariable regression models were performed. Taking 80 mg/day of iron improved child behaviour when women had low iron stores but worsened it when mothers had normal-high iron stores, except for depressive and attention/hyperactivity problems. Taking 20 mg/day of iron improved behaviour only in those children whose mothers had SF > 65 µg/L in early pregnancy. Additionally, executive functioning improved at high doses of prenatal iron when maternal baseline SF < 15 µg/L. Adjusting prenatal iron supplementation to both maternal baseline Hb levels and iron stores reduces behavioural problems in 4-year-old children.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.
Thematic Areas: Ciências biológicas ii Enfermagem Farmacia General medicine Medicina i Medicina ii Nutrição Nutrition & dietetics Nutrition and dietetics Obstetrics and gynecology Pediatrics Pediatrics, perinatology and child health Public health, environmental and occupational health Saúde coletiva
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nuria.voltas@urv.cat victoria.arija@urv.cat josefa.canals@urv.cat carmen.hernandez@urv.cat lucia.iglesias@urv.cat
Author identifier: 0000-0001-8855-0282 0000-0002-1758-0975 0000-0002-6209-9558 0000-0001-6328-8679 0000-0001-7131-4144
Record's date: 2024-01-13
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.13595
Papper original source: Maternal And Child Nutrition. 20 (1): e13595-e13595
APA: Iglesias-Vázquez, L; Canals, J; Hernández-Martínez, C; Voltas, N; Arija, V (2024). Prenatal iron supplementation adjusted to maternal iron stores reduces behavioural problems in 4-year-old children. Maternal And Child Nutrition, 20(1), e13595-e13595. DOI: 10.1111/mcn.13595
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1111/mcn.13595
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV