Articles producció científica> Bioquímica i Biotecnologia

Olive oil consumption, plasma metabolites, and risk of type 2 diabetes and cardiovascular disease

  • Identification data

    Identifier: imarina:9332909
  • Authors:

    García-Gavilán, JF
    Babio, N
    Toledo, E
    Semnani-Azad, Z
    Razquin, C
    Dennis, C
    Deik, A
    Corella, D
    Estruch, R
    Ros, E
    Fitó, M
    Arós, F
    Fiol, M
    Lapetra, J
    Lamuela-Raventos, R
    Clish, C
    Ruiz-Canela, M
    Martínez-González, MA
    Hu, F
    Salas-Salvadó, J
    Guasch-Ferré, M
  • Others:

    Author, as appears in the article.: García-Gavilán, JF; Babio, N; Toledo, E; Semnani-Azad, Z; Razquin, C; Dennis, C; Deik, A; Corella, D; Estruch, R; Ros, E; Fitó, M; Arós, F; Fiol, M; Lapetra, J; Lamuela-Raventos, R; Clish, C; Ruiz-Canela, M; Martínez-González, MA; Hu, F; Salas-Salvadó, J; Guasch-Ferré, M
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Salas Salvadó, Jorge
    Keywords: Type 2 diabetes Olive oil Metabolomics Mediterranean diet Cardiovascular disease type 2 diabetes questionnaire polyphenols mortality metabolomics marker humans fat density-lipoprotein cardiovascular disease acylcarnitines
    Abstract: Olive oil consumption has been inversely associated with the risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). However, the impact of olive oil consumption on plasma metabolites remains poorly understood. This study aims to identify plasma metabolites related to total and specific types of olive oil consumption, and to assess the prospective associations of the identified multi-metabolite profiles with the risk of T2D and CVD.The discovery population included 1837 participants at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) trial with available metabolomics data at baseline. Olive oil consumption was determined through food-frequency questionnaires (FFQ) and adjusted for total energy. A total of 1522 participants also had available metabolomics data at year 1 and were used as the internal validation sample. Plasma metabolomics analyses were performed using LC-MS. Cross-sectional associations between 385 known candidate metabolites and olive oil consumption were assessed using elastic net regression analysis. A 10-cross-validation (CV) procedure was used, and Pearson correlation coefficients were assessed between metabolite-weighted models and FFQ-derived olive oil consumption in each pair of training-validation data sets within the discovery sample. We further estimated the prospective associations of the identified plasma multi-metabolite profile with incident T2D and CVD using multivariable Cox regression models.We identified a metabolomic signature for the consumption of total olive oil (with 74 metabolites), VOO (with 78 metabolites), and COO (with 17 metabolites), including several lipids, acylcarnitines, and amino acids. 10-CV Pearson correlation coefficients between total olive oil consumption derived from FFQs and the multi-metabolite profile were 0.40 (95% CI 0.37, 0.44) and 0.27 (95% CI 0.22, 0.31) for the discovery and validation sample, respectively. We identified several overlapping and distinct metabolites according to the type of olive oil consumed. The baseline metabolite profiles of total and extra virgin olive oil were inversely associated with CVD incidence (HR per 1SD: 0.79; 95% CI 0.67, 0.92 for total olive oil and 0.70; 0.59, 0.83 for extra virgin olive oil) after adjustment for confounders. However, no significant associations were observed between these metabolite profiles and T2D incidence.This study reveals a panel of plasma metabolites linked to the consumption of total and specific types of olive oil. The metabolite profiles of total olive oil consumption and extra virgin olive oil were associated with a decreased risk of incident CVD in a high cardiovascular-risk Mediterranean population, though no associations were observed with T2D incidence.The PREDIMED trial was registered at ISRCTN ( http://www.isrctn.com/ , ISRCTN35739639).© 2023. The Author(s).
    Thematic Areas: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jesusfrancisco.garcia@urv.cat jesusfrancisco.garcia@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://cardiab.biomedcentral.com/articles/10.1186/s12933-023-02066-1
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Cardiovascular Diabetology. 22 (1): 340-340
    APA: García-Gavilán, JF; Babio, N; Toledo, E; Semnani-Azad, Z; Razquin, C; Dennis, C; Deik, A; Corella, D; Estruch, R; Ros, E; Fitó, M; Arós, F; Fiol, M; L (2023). Olive oil consumption, plasma metabolites, and risk of type 2 diabetes and cardiovascular disease. Cardiovascular Diabetology, 22(1), 340-340. DOI: 10.1186/s12933-023-02066-1
    Article's DOI: 10.1186/s12933-023-02066-1
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Type 2 diabetes
    Olive oil
    Metabolomics
    Mediterranean diet
    Cardiovascular disease
    type 2 diabetes
    questionnaire
    polyphenols
    mortality
    metabolomics
    marker
    humans
    fat
    density-lipoprotein
    cardiovascular disease
    acylcarnitines
    Saúde coletiva
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar