Author, as appears in the article.: Chirlaque MD; Peris-Bonet R; Sánchez A; Cruz O; Marcos-Gragera R; Gutiérrez-Ávila G; Quirós-García JR; Almela-Vich F; López de Munain A; Sánchez MJ; Franch-Sureda P; Ardanaz E; Galceran J; Martos C; Salmerón D; Gatta G; Botta L; Cañete A; The Spanish Childhood Cancer Epidemiology Working Group
Department: Medicina i Cirurgia
URV's Author/s: Galceran Padrós, Jaume Josep Maria
Keywords: Time trends Survival Spain Population-based cancer registries Paediatric oncology Incidence Childhood cns tumours Adolescent cns tumours
Abstract: Central nervous system (CNS) neoplasms are highly frequent solid tumours in children and adolescents. While some studies have shown a rise in their incidence in Europe, others have not. Survival remains limited. We addressed two questions about these tumours in Spain: (1) Is incidence increasing? and (2) Has survival improved?This population-based study included 1635 children and 328 adolescents from 11 population-based cancer registries with International Classification of Childhood Cancer Group III tumours, incident in 1983-2007. Age-specific and age-standardised (world population) incidence rates (ASRws) were calculated. Incidence time trends were characterised using annual percent change (APC) obtained with Joinpoint. Cases from 1991 to 2005 (1171) were included in Kaplan-Meier survival analyses, and the results were evaluated with log-rank and log-rank for trend tests. Children's survival was age-standardised using: (1) the age distribution of cases and the corresponding trends assessed with Joinpoint; and (2) European weights for comparison with Europe.ASRw 1983-2007: children: 32.7 cases/106; adolescents: 23.5 cases/106. The overall incidence of all tumours increased across 1983-2007 in children and adolescents. Considering change points, the APCs were: (1) children: 1983-1993, 4.3%^ (1.1; 7.7); 1993-2007, -0.2% (-1.9; 1.6); (2) adolescents: 1983-2004: 2.9%^ (0.9; 4.9); 2004-2007: -7.7% (-40; 41.9). For malignant tumours, the trends were not significant. 5-year survival was 65% (1991-2005), with no significant trends (except for non-malignant tumours).CNS tumour incidence in Spain was found to be similar to that in Europe. Rises in incidence may be mostly attributable to changes in the registration of non-malignant tumours. The overall malignant CNS tumour trend was compatible with reports for Southern Europe. Survival was lower than in Europe, without improvement over time. We provide a baseline for assessing current paediatric oncology achievements and incidence in respect of childhood and adolescent CNS tumours.
Thematic Areas: Oncology Medicina iii Cancer research
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jaumejosepmaria.galceran@urv.cat
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6694/15/24/5889
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cancers. 15 (24):
APA: Chirlaque MD; Peris-Bonet R; Sánchez A; Cruz O; Marcos-Gragera R; Gutiérrez-Ávila G; Quirós-García JR; Almela-Vich F; López de Munain A; Sánchez MJ; F (2023). Childhood and Adolescent Central Nervous System Tumours in Spain: Incidence and Survival over 20 Years: A Historical Baseline for Current Assessment. Cancers, 15(24), -. DOI: 10.3390/cancers15245889
Article's DOI: 10.3390/cancers15245889
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV