Articles producció científica> Medicina i Cirurgia

Type 2 diabetes and succinate: unmasking an age-old molecule

  • Identification data

    Identifier: imarina:9333929
    Authors:
    Fernández-Veledo, SMarsal-Beltran, AVendrell, J
    Abstract:
    Beyond their conventional roles in intracellular energy production, some traditional metabolites also function as extracellular messengers that activate cell-surface G-protein-coupled receptors (GPCRs) akin to hormones and neurotransmitters. These signalling metabolites, often derived from nutrients, the gut microbiota or the host's intermediary metabolism, are now acknowledged as key regulators of various metabolic and immune responses. This review delves into the multi-dimensional aspects of succinate, a dual metabolite with roots in both the mitochondria and microbiome. It also connects the dots between succinate's role in the Krebs cycle, mitochondrial respiration, and its double-edge function as a signalling transmitter within and outside the cell. We aim to provide an overview of the role of the succinate-succinate receptor 1 (SUCNR1) axis in diabetes, discussing the potential use of succinate as a biomarker and the novel prospect of targeting SUCNR1 to manage complications associated with diabetes. We further propose strategies to manipulate the succinate-SUCNR1 axis for better diabetes management; this includes pharmacological modulation of SUCNR1 and innovative approaches to manage succinate concentrations, such as succinate administration and indirect strategies, like microbiota modulation. The dual nature of succinate, both in terms of origins and roles, offers a rich landscape for understanding the intricate connections within metabolic diseases, like diabetes, and indicates promising pathways for developing new therapeutic strategies.© 2024. The Author(s).
  • Others:

    Author, as appears in the article.: Fernández-Veledo, S; Marsal-Beltran, A; Vendrell, J
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    URV's Author/s: Fernandez Veledo, Sonia / MARSAL BELTRAN, ANNA / Vendrell Ortega, Juan José
    Keywords: Type 2 diabetes Type 1 diabetes Sucnr1 Succinate Review Receptor gpr91 Nafld Microbiota Gestational diabetes Diabetic retinopathy Diabetic nephropathy vegf release type 2 diabetes type 1 diabetes sucnr1 succinate signal review renin release obesity nafld microbiota metabolism improvement high glucose gestational diabetes diabetic retinopathy cells antagonist
    Abstract: Beyond their conventional roles in intracellular energy production, some traditional metabolites also function as extracellular messengers that activate cell-surface G-protein-coupled receptors (GPCRs) akin to hormones and neurotransmitters. These signalling metabolites, often derived from nutrients, the gut microbiota or the host's intermediary metabolism, are now acknowledged as key regulators of various metabolic and immune responses. This review delves into the multi-dimensional aspects of succinate, a dual metabolite with roots in both the mitochondria and microbiome. It also connects the dots between succinate's role in the Krebs cycle, mitochondrial respiration, and its double-edge function as a signalling transmitter within and outside the cell. We aim to provide an overview of the role of the succinate-succinate receptor 1 (SUCNR1) axis in diabetes, discussing the potential use of succinate as a biomarker and the novel prospect of targeting SUCNR1 to manage complications associated with diabetes. We further propose strategies to manipulate the succinate-SUCNR1 axis for better diabetes management; this includes pharmacological modulation of SUCNR1 and innovative approaches to manage succinate concentrations, such as succinate administration and indirect strategies, like microbiota modulation. The dual nature of succinate, both in terms of origins and roles, offers a rich landscape for understanding the intricate connections within metabolic diseases, like diabetes, and indicates promising pathways for developing new therapeutic strategies.© 2024. The Author(s).
    Thematic Areas: Saúde coletiva Química Medicina veterinaria Medicina i Internal medicine Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: anna.marsal@urv.cat sonia.fernandez@urv.cat anna.marsal@urv.cat juanjose.vendrell@urv.cat
    Author identifier: 0000-0003-2906-3788 0000-0002-6994-6115
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://link.springer.com/article/10.1007/s00125-023-06063-7
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Diabetologia. 67 (3): 430-
    APA: Fernández-Veledo, S; Marsal-Beltran, A; Vendrell, J (2024). Type 2 diabetes and succinate: unmasking an age-old molecule. Diabetologia, 67(3), 430-. DOI: 10.1007/s00125-023-06063-7
    Article's DOI: 10.1007/s00125-023-06063-7
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Type 2 diabetes
    Type 1 diabetes
    Sucnr1
    Succinate
    Review
    Receptor gpr91
    Nafld
    Microbiota
    Gestational diabetes
    Diabetic retinopathy
    Diabetic nephropathy
    vegf release
    type 2 diabetes
    type 1 diabetes
    sucnr1
    succinate
    signal
    review
    renin release
    obesity
    nafld
    microbiota
    metabolism
    improvement
    high glucose
    gestational diabetes
    diabetic retinopathy
    cells
    antagonist
    Saúde coletiva
    Química
    Medicina veterinaria
    Medicina i
    Internal medicine
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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