Author, as appears in the article.: Glenn, MC; Hernandez, V; Saez, J; Followill, DS; Howell, RM; Pollard-Larkin, JM; Zhou, SH; Kry, SF
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Hernandez Masgrau, Victor
Keywords: Radiotherapy, intensity-modulated Radiotherapy planning, computer-assisted Radiotherapy dosage Radiometry Quality-assurance Quality assurance Plan complexity Phantoms, imaging Particle accelerators Neck Modulation Metrics Iroc Intensity-modulated radiotherapy Index Imrt qa Humans Head Dosimetry Credentialing Beam Anthropomorphic phantom
Abstract: Previous works indicate that intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) plans that are highly complex may produce more errors in dose calculation and treatment delivery. Multiple complexity metrics have been proposed and associated with IMRT QA results, but their relationships with plan performance using in situ dose measurements have not been thoroughly investigated. This study aimed to evaluate the relationships between IMRT treatment plan complexity and anthropomorphic phantom performance in order to assess the extent to which plan complexity is related to dosimetric performance in the IROC phantom credentialing program. Sixteen complexity metrics, including the modulation complexity score (MCS), several modulation indices, and total monitor units (MU) delivered, were evaluated for 343 head and neck phantom irradiations, comprising both IMRT (step-and-shoot and sliding window techniques) and VMAT. Spearman's correlations were used to explore the relationship between complexity and plan performance, as measured by the dosimetric differences between the treatment planning system (TPS) and thermoluminescent dosimeter (TLD) measurement, as well as film gamma analysis. Relationships were likewise determined for several combinations of subpopulations, based on the linear accelerator model, TPS used, and delivery modality. Evaluation of the complexity metrics presented here yielded no significant relationships (p > 0.01, Bonferroni-corrected) and all correlations were weak (less than +/- 0.30). These results indicate that complexity metrics have limited predictive utility in assessing plan performance in multi-institutional comparisons of IMRT plans. Other factors affecting plan accuracy, such as dosimetric modeling or multileaf collimator (MLC) performance, should be investigated to determine a more probable cause for dose delivery errors.
Thematic Areas: Saúde coletiva Radiology, nuclear medicine and imaging Radiology, nuclear medicine & medical imaging Radiological and ultrasound technology Psicología Odontología Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Engineering, biomedical Engenharias iv Engenharias iii Engenharias ii Ciências biológicas ii Ciências biológicas i Ciência da computação Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: victor.hernandez@urv.cat
Author identifier: 0000-0003-3770-8486
Record's date: 2024-06-28
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://iopscience.iop.org/article/10.1088/1361-6560/aae29e
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Physics In Medicine And Biology. 63 (20): 205015-
APA: Glenn, MC; Hernandez, V; Saez, J; Followill, DS; Howell, RM; Pollard-Larkin, JM; Zhou, SH; Kry, SF (2018). Treatment plan complexity does not predict IROC Houston anthropomorphic head and neck phantom performance. Physics In Medicine And Biology, 63(20), 205015-. DOI: 10.1088/1361-6560/aae29e
Article's DOI: 10.1088/1361-6560/aae29e
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV