Author, as appears in the article.: Margara-Escudero, HJ; Paz-Graniel, I; García-Gavilán, J; Ruiz-Canela, M; Sun, Q; Clish, CB; Toledo, E; Corella, D; Estruch, R; Ros, E; Castañer, O; Arós, F; Fiol, M; Guasch-Ferré, M; Lapetra, J; Razquin, C; Dennis, C; Deik, A; Li, J; Gómez-Gracia, E; Babio, N; Martínez-González, MA; Hu, FB; Salas-Salvadó, J
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge
Keywords: Type 2 diabetes Risk factors Plasma Metabolomics Male Legumes Humans Female Fabaceae Diet, mediterranean Diabetes mellitus, type 2 Cross-sectional studies Cardiovascular diseases Cardiovascular disease Aged Acid type 2 diabetes questionnaire plasma metabolomics meat legumes diet cardiovascular disease biomarkers
Abstract: Legume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential association between plasma metabolites associated with legume consumption and the risk of cardiometabolic diseases has never been explored. Therefore, we aimed to identify a metabolite signature of legume consumption, and subsequently investigate its potential association with the incidence of T2D and CVD.The current cross-sectional and longitudinal analysis was conducted in 1833 PREDIMED study participants (mean age 67 years, 57.6% women) with available baseline metabolomic data. A subset of these participants with 1-year follow-up metabolomics data (n = 1522) was used for internal validation. Plasma metabolites were assessed through liquid chromatography-tandem mass spectrometry. Cross-sectional associations between 382 different known metabolites and legume consumption were performed using elastic net regression. Associations between the identified metabolite profile and incident T2D and CVD were estimated using multivariable Cox regression models.Specific metabolic signatures of legume consumption were identified, these included amino acids, cortisol, and various classes of lipid metabolites including diacylglycerols, triacylglycerols, plasmalogens, sphingomyelins and other metabolites. Among these identified metabolites, 22 were negatively and 18 were positively associated with legume consumption. After adjustment for recognized risk factors and legume consumption, the identified legume metabolite profile was inversely associated with T2D incidence (hazard ratio (HR) per 1 SD: 0.75, 95% CI 0.61-0.94; p = 0.017), but not with CVD incidence risk (1.01, 95% CI 0.86-1.19; p = 0.817) over the follow-up period.This study identified a set of 40 metabolites associated with legume consumption and with a reduced risk of T2D development in a Mediterranean population at high risk of cardiovascular disease.ISRCTN35739639.© 2024. The Author(s).
Thematic Areas: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-3204-6877 0000-0002-3204-6877 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://cardiab.biomedcentral.com/articles/10.1186/s12933-023-02111-z
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cardiovascular Diabetology. 23 (1): 38-38
APA: Margara-Escudero, HJ; Paz-Graniel, I; García-Gavilán, J; Ruiz-Canela, M; Sun, Q; Clish, CB; Toledo, E; Corella, D; Estruch, R; Ros, E; Castañer, O; Ar (2024). Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease. Cardiovascular Diabetology, 23(1), 38-38. DOI: 10.1186/s12933-023-02111-z
Article's DOI: 10.1186/s12933-023-02111-z
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV