Author, as appears in the article.: Manocchio, F; Bravo, FI; Helfer, G; Muguerza, B
Department: Bioquímica i Biotecnologia
e-ISSN: 2076-3921
URV's Author/s: Bravo Vázquez, Francisca Isabel / Manocchio, Francesca / Muguerza Marquínez, Maria Begoña
Keywords: Thyroid-hormone Seasonal Photoperiod Phenolic compounds Neurotroph Hippocampus Bdnf Antioxidant-rich fruit sweet seasonal polyphenols photoperiod neurotroph memory hippocampus health extraction expression cells bdnf antioxidant-rich fruit antioxidant properties anthocyanins
Abstract: The photoperiod is the main environmental cue that drives seasonal adaptive responses in reproduction, behavior, and metabolism in seasonal animals. Increasing evidence suggests that (poly)phenols contained in fruits can also modulate seasonal rhythms. (Poly)phenol-rich diets are associated with an improvement in cognitive function and neuroprotection due to their anti-inflammatory and antioxidative properties. However, it is unknown whether cherries affect neuroprotection in a photoperiod-dependent manner. To test this, F344 rats were exposed to L6 (6 h light/day), L12 (12 h light/day) and L18 (18 h light/day) photoperiods and fed a standard chow diet supplemented with either a control, lyophilized cherry 1 or cherry 2 with distinctive phenolic hallmarks. Physiological parameters (body weight, eating pattern index (EPI), testosterone, T4/T3) and hypothalamic key genes (Dio2, Dio3, Raldh1 and Ghrh) were strongly regulated by the photoperiod and/or fruit consumption. Importantly, we show for the first time that neurotrophs (Bdnf, Sod1 and Gpx1) in the hippocampus are also regulated by the photoperiod. Furthermore, the consumption of cherry 2, which was richer in total flavonols, but not cherry 1, which was richer in total anthocyanins and flavanols, enhanced neuroprotection in the hippocampus. Our results show that the seasonal consumption of cherry with a specific phenolic composition plays an important role in the hippocampal activation of neuroprotection in a photoperiod-dependent manner.
Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat francesca.manocchio@estudiants.urv.cat francesca.manocchio@estudiants.urv.cat
Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588
Record's date: 2024-03-09
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2076-3921/13/1/72
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Antioxidants. 13 (1): 72-
APA: Manocchio, F; Bravo, FI; Helfer, G; Muguerza, B (2024). Cherries with Different Geographical Origins Regulate Neuroprotection in a Photoperiod-Dependent Manner in F344 Rats. Antioxidants, 13(1), 72-. DOI: 10.3390/antiox13010072
Article's DOI: 10.3390/antiox13010072
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV