Articles producció científica> Bioquímica i Biotecnologia

Cherries with Different Geographical Origins Regulate Neuroprotection in a Photoperiod-Dependent Manner in F344 Rats

  • Identification data

    Identifier: imarina:9335144
  • Authors:

    Manocchio, F
    Bravo, FI
    Helfer, G
    Muguerza, B
    Antioxidants
    10.3390/antiox13010072
    Antioxidants. 13 (1): 72-
  • Others:

    Author, as appears in the article.: Manocchio, F; Bravo, FI; Helfer, G; Muguerza, B
    Department: Bioquímica i Biotecnologia
    e-ISSN: 2076-3921
    URV's Author/s: Bravo Vázquez, Francisca Isabel / Manocchio, Francesca / Muguerza Marquínez, Maria Begoña
    Keywords: Thyroid-hormone Seasonal Photoperiod Phenolic compounds Neurotroph Hippocampus Bdnf Antioxidant-rich fruit sweet seasonal polyphenols photoperiod neurotroph memory hippocampus health extraction expression cells bdnf antioxidant-rich fruit antioxidant properties anthocyanins
    Abstract: The photoperiod is the main environmental cue that drives seasonal adaptive responses in reproduction, behavior, and metabolism in seasonal animals. Increasing evidence suggests that (poly)phenols contained in fruits can also modulate seasonal rhythms. (Poly)phenol-rich diets are associated with an improvement in cognitive function and neuroprotection due to their anti-inflammatory and antioxidative properties. However, it is unknown whether cherries affect neuroprotection in a photoperiod-dependent manner. To test this, F344 rats were exposed to L6 (6 h light/day), L12 (12 h light/day) and L18 (18 h light/day) photoperiods and fed a standard chow diet supplemented with either a control, lyophilized cherry 1 or cherry 2 with distinctive phenolic hallmarks. Physiological parameters (body weight, eating pattern index (EPI), testosterone, T4/T3) and hypothalamic key genes (Dio2, Dio3, Raldh1 and Ghrh) were strongly regulated by the photoperiod and/or fruit consumption. Importantly, we show for the first time that neurotrophs (Bdnf, Sod1 and Gpx1) in the hippocampus are also regulated by the photoperiod. Furthermore, the consumption of cherry 2, which was richer in total flavonols, but not cherry 1, which was richer in total anthocyanins and flavanols, enhanced neuroprotection in the hippocampus. Our results show that the seasonal consumption of cherry with a specific phenolic composition plays an important role in the hippocampal activation of neuroprotection in a photoperiod-dependent manner.
    Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: franciscaisabel.bravo@urv.cat francesca.manocchio@estudiants.urv.cat francesca.manocchio@estudiants.urv.cat begona.muguerza@urv.cat
    Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2076-3921/13/1/72
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Antioxidants. 13 (1): 72-
    APA: Manocchio, F; Bravo, FI; Helfer, G; Muguerza, B (2024). Cherries with Different Geographical Origins Regulate Neuroprotection in a Photoperiod-Dependent Manner in F344 Rats. Antioxidants, 13(1), 72-. DOI: 10.3390/antiox13010072
    Article's DOI: 10.3390/antiox13010072
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Cell Biology,Chemistry, Medicinal,Clinical Biochemistry,Food Science,Food Science & Technology,Molecular Biology,Physiology
    Thyroid-hormone
    Seasonal
    Photoperiod
    Phenolic compounds
    Neurotroph
    Hippocampus
    Bdnf
    Antioxidant-rich fruit
    sweet
    seasonal
    polyphenols
    photoperiod
    neurotroph
    memory
    hippocampus
    health
    extraction
    expression
    cells
    bdnf
    antioxidant-rich fruit
    antioxidant properties
    anthocyanins
    Química
    Physiology
    Molecular biology
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias ii
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
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