Articles producció científica> Medicina i Cirurgia

SARS-CoV-2 infection in patients with primary Sjögren syndrome: Characterization and outcomes of 51 patients

  • Identification data

    Identifier: imarina:9351816
    Authors:
    Brito-Zerón PBrito-Zerón PMelchor SSeror RSeror RPriori RPriori RSolans RSolans RKostov BKostov BBaldini CCarubbi FCarubbi FCallejas JLGuisado-Vasco PHernández-Molina GHernández-Molina GPasoto SGPasoto SGValim VValim VSisó-Almirall ASisó-Almirall AMariette XCarreira PRamos-Casals MBrito-Zerón PMorcillo CFlores-Chávez AAcar-Denizli NHorvath IFSzanto ATarr TMandl TOlsson PLi XXu BBaldini CBombardieri SGottenberg JEGandolfo SDe Vita SGiardina FSánchez-Guerrero JKruize AAHinrichs AIsenberg DRischmueller MDownie-Doyle SKwok SKPark SHNordmark GSuzuki YKawano MGiacomelli RDevauchelle-Pensec VSaraux AHofauer BKnopf ABootsma HVissink AMorel JVollenveider CAtzeni FRetamozo SMoça Trevisano VArmagan BKilic LKalyoncu UConsani-Fernández SCallejas JLLópez-Dupla MPérez-Alvarez RAkasbi MSánchez I
    Abstract:
    Objective: To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS. Methods: We searched for patients with primary SS presenting with SARS-CoV-2 infection (defined following and according to the European Centre for Disease Prevention and Control guidelines) among those included in the Big Data Sjögren Registry, an international, multicentre registry of patients diagnosed according to the 2002/2016 classification criteria. Results: A total of 51 patients were included in the study (46 women, mean age at diagnosis of infection of 60 years). According to the number of patients with primary SS evaluated in the Registry (n = 8211), the estimated frequency of SARS-CoV-2 infection was 0.62% (95% CI 0.44, 0.80). All but two presented with symptoms suggestive of COVID-19, including fever (82%), cough (57%), dyspnoea (39%), fatigue/myalgias (27%) and diarrhoea (24%), and the most frequent abnormalities included raised lactate dehydrogenase (LDH) (88%), CRP (81%) and D-dimer (82%) values, and lymphopenia (70%). Infection was managed at home in 26 (51%) cases and 25 (49%) required hospitalization (five required admission to ICU, four died). Compared with patients managed at home, those requiring hospitalization had higher odds of having lymphopenia as laboratory abnormality (adjusted OR 21.22, 95% CI 2.39, 524.09). Patients with comorbidities had an older age (adjusted OR 1.05, 95% CI 1.00, 1.11) and showed a risk for hospital admission six times higher than those without (adjusted OR 6.01, 95% CI 1.72, 23.51) in the multivariate analysis. Conclusion: Baseline comorbidities were a key risk factor for a more complicated COVID-19 in patients with primary SS, with higher rates of hospitalization and poor outcomes in comparison with patients without co
  • Others:

    Author, as appears in the article.: Brito-Zerón P; Brito-Zerón P; Melchor S; Seror R; Seror R; Priori R; Priori R; Solans R; Solans R; Kostov B; Kostov B; Baldini C; Carubbi F; Carubbi F; Callejas JL; Guisado-Vasco P; Hernández-Molina G; Hernández-Molina G; Pasoto SG; Pasoto SG; Valim V; Valim V; Sisó-Almirall A; Sisó-Almirall A; Mariette X; Carreira P; Ramos-Casals M; Brito-Zerón P; Morcillo C; Flores-Chávez A; Acar-Denizli N; Horvath IF; Szanto A; Tarr T; Mandl T; Olsson P; Li X; Xu B; Baldini C; Bombardieri S; Gottenberg JE; Gandolfo S; De Vita S; Giardina F; Sánchez-Guerrero J; Kruize AA; Hinrichs A; Isenberg D; Rischmueller M; Downie-Doyle S; Kwok SK; Park SH; Nordmark G; Suzuki Y; Kawano M; Giacomelli R; Devauchelle-Pensec V; Saraux A; Hofauer B; Knopf A; Bootsma H; Vissink A; Morel J; Vollenveider C; Atzeni F; Retamozo S; Moça Trevisano V; Armagan B; Kilic L; Kalyoncu U; Consani-Fernández S; Callejas JL; López-Dupla M; Pérez-Alvarez R; Akasbi M; Sánchez I
    Department: Medicina i Cirurgia
    URV's Author/s: López Dupla, Jesús Miguel
    Keywords: Comorbidities Covid-19 Outcomes Primary ss Sars-cov-2
    Abstract: Objective: To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS. Methods: We searched for patients with primary SS presenting with SARS-CoV-2 infection (defined following and according to the European Centre for Disease Prevention and Control guidelines) among those included in the Big Data Sjögren Registry, an international, multicentre registry of patients diagnosed according to the 2002/2016 classification criteria. Results: A total of 51 patients were included in the study (46 women, mean age at diagnosis of infection of 60 years). According to the number of patients with primary SS evaluated in the Registry (n = 8211), the estimated frequency of SARS-CoV-2 infection was 0.62% (95% CI 0.44, 0.80). All but two presented with symptoms suggestive of COVID-19, including fever (82%), cough (57%), dyspnoea (39%), fatigue/myalgias (27%) and diarrhoea (24%), and the most frequent abnormalities included raised lactate dehydrogenase (LDH) (88%), CRP (81%) and D-dimer (82%) values, and lymphopenia (70%). Infection was managed at home in 26 (51%) cases and 25 (49%) required hospitalization (five required admission to ICU, four died). Compared with patients managed at home, those requiring hospitalization had higher odds of having lymphopenia as laboratory abnormality (adjusted OR 21.22, 95% CI 2.39, 524.09). Patients with comorbidities had an older age (adjusted OR 1.05, 95% CI 1.00, 1.11) and showed a risk for hospital admission six times higher than those without (adjusted OR 6.01, 95% CI 1.72, 23.51) in the multivariate analysis. Conclusion: Baseline comorbidities were a key risk factor for a more complicated COVID-19 in patients with primary SS, with higher rates of hospitalization and poor outcomes in comparison with patients without comorbidities.
    Thematic Areas: Biotecnología Ciência de alimentos Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Ensino Farmacia General medicine Interdisciplinar Medicina i Medicina ii Medicina iii Odontología Pharmacology (medical) Rheumatology Saúde coletiva
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jesusmiguel.lopez@urv.cat
    Author identifier: 0000-0002-9141-2523
    Record's date: 2024-02-10
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://academic.oup.com/rheumatology/article/60/6/2946/6033953?login=false
    Papper original source: Rheumatology. 60 (6): 2946-2957
    APA: Brito-Zerón P; Brito-Zerón P; Melchor S; Seror R; Seror R; Priori R; Priori R; Solans R; Solans R; Kostov B; Kostov B; Baldini C; Carubbi F; Carubbi F (2021). SARS-CoV-2 infection in patients with primary Sjögren syndrome: Characterization and outcomes of 51 patients. Rheumatology, 60(6), 2946-2957. DOI: 10.1093/rheumatology/keaa748
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1093/rheumatology/keaa748
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Pharmacology (Medical),Rheumatology
    Comorbidities
    Covid-19
    Outcomes
    Primary ss
    Sars-cov-2
    Biotecnología
    Ciência de alimentos
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Ensino
    Farmacia
    General medicine
    Interdisciplinar
    Medicina i
    Medicina ii
    Medicina iii
    Odontología
    Pharmacology (medical)
    Rheumatology
    Saúde coletiva
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