Author, as appears in the article.: Pujol, M; Méndez, M; Fernández, E
Department: Química Física i Inorgànica
URV's Author/s: Fernández Gutiérrez, Maria Elena / Pujol Martí, Mireia
Keywords: Substitution
Abstract: The key to a successful C-B activation is to discriminate between two geminal boryl moieties that are exposed to the same reaction conditions. Here we describe a stereoselective C-B activation of beta,beta-diboryl acrylates forming exclusively the (Z)-alpha-borylalkenyl copper(I) key intermediate, for subsequent allylic alkylation reactions. The new borylated (Z)-skipped dienoates followed a feasible iodo-lactonization sequence for the preparation of borylated lactone cores, which can be used in drug discovery.
Thematic Areas: Química
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: mireia.pujol@urv.cat mariaelena.fernandez@urv.cat
Author identifier: 0000-0001-9025-1791
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://pubs.acs.org/doi/full/10.1021/acs.orglett.3c03640
APA: Pujol, M., Méndez, M., & Fernández, E. (2024). Stereoselective Control of the Cu Activation of β,β-Diboryl Acrylates for Allylic Coupling Protocols with Concomitant Lactonization. Organic letters, 26(14), 2821–2826. https://doi.org/10.1021/acs.orglett.3c03640
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1021/acs.orglett.3c03640
Journal publication year: 2023
Publication Type: info:eu-repo/semantics/article
Repositori URV