Author, as appears in the article.: Morales-Navas M; Perez-Fernandez C; Castaño-Castaño S; Sánchez-Gil A; Colomina MT; Leinekugel X; Sánchez-Santed F
Department: Psicologia
URV's Author/s: Colomina Fosch, Maria Teresa
Keywords: Autism Chlorpyrifos Pesticides Sociability Valproic acid
Abstract: In recent years, exposures to organophosphate pesticide have been highlighted as a possible cause or aggravating factor of autism spectrum disorder (ASD). The present study examined if Wistar rats prenatally exposed to chlorpyrifos (CPF) at a dose of 1 mg/kg in GD 12.5-15.5 could express similar behaviors to those exposed to valproic acid (VPA, 400 mg/kg) during the same administration window, which is an accepted animal model of autism. The 3-chambered test was employed to evaluate sociability and reaction to social novelty in two experiments, the first in adolescence and the second in adulthood. The results obtained in this study show that animals prenatally treated with CPF or VPA show a similar behavioral phenotype compared to the control group (CNT). In adolescence, the CPF animals showed a negative index in the reaction to social novelty, followed closely by the VPA, while both experimental groups showed a recovery in this aspect during adulthood. This study therefore provides evidence to suggest that prenatal exposure to CPF in rats could have similar effects on certain components of sociability to those seen in autistic models.© 2024. The Author(s).
Thematic Areas: Ciências biológicas i Ciencias sociales Developmental and educational psychology Educació General medicine Interdisciplinar Medicina i Medicina ii Psicología Psychology Psychology, developmental Saúde coletiva
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: mariateresa.colomina@urv.cat
Author identifier: 0000-0002-5619-4874
Record's date: 2024-03-23
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://link.springer.com/article/10.1007/s10803-024-06263-z
Papper original source: Journal Of Autism And Developmental Disorders.
APA: Morales-Navas M; Perez-Fernandez C; Castaño-Castaño S; Sánchez-Gil A; Colomina MT; Leinekugel X; Sánchez-Santed F (2024). Sociability: Comparing the Effect of Chlorpyrifos with Valproic Acid. Journal Of Autism And Developmental Disorders, (), -. DOI: 10.1007/s10803-024-06263-z
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1007/s10803-024-06263-z
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV