Author, as appears in the article.: Peiró ÓM; Delgado-Cornejo JR; Sánchez-Giménez R; del-Moral-Ronda V; Lal-Trehan N; Rocamora-Horrach M; Carrasquer A; Peraire J; Fort-Gallifa I; Bardaji A
Department: Medicina i Cirurgia
URV's Author/s: Bardají Ruiz, Alfredo / Carrasquer Cucarella, Ana Maria / Peiró Ibáñez, Óscar Manuel / Peraire Forner, José Joaquin
Keywords: Troponin Sars-cov-2 Prognostic Myocardial injury Covid-19
Abstract: Introduction: The prognostic ability of myocardial injury across different waves of the COVID-19 pandemic is not well established. The purpose of this study was to evaluate the prevalence and prognostic implications of myocardial injury in the first and sixth wave of COVID-19. Methods: We conducted a retrospective observational study that included patients admitted to the emergency department with COVID-19 with data on concentrations of cardiac troponin during the first and sixth wave. We compared the prevalence of myocardial injury and its predictive capacity for 30-day all-cause death in both waves. Results and discussion: A total of 346 patients were included (1st wave 199 and 6th wave 147 patients). The prevalence of myocardial injury was 21% with non-significant differences between waves. Myocardial injury was associated, in both waves, with a higher prevalence of comorbidities and with an increased risk of 30-day all-cause death [1st wave HR: 3.73 (1.84–7.55); p < 0.001 and 6th wave HR: 3.13 (1.23–7.92); p = 0.016], with non-significant differences in predictive capacity between groups after ROC curve analysis [AUC: 1st wave 0.829 (95% CI: 0.764–0.895) and 6th wave 0.794 (95% CI: 0.711–0.876)]. As limitations, this is a retrospective study with a relatively small simple size and troponin assay was performed at the discretion of the emergency physician so selection bias could be present. In conclusion, the prevalence of myocardial injury and its prognostic capacity was similar in both waves despite vaccination programs. Myocardial injury predicts short-term mortality in all COVID-19 patients, so they should be treated intensively.
Thematic Areas: Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat joaquim.peraire@urv.cat alfredo.bardaji@urv.cat anamaria.carrasquer@urv.cat oscarmanuel.peiro@urv.cat
Author identifier: 0000-0001-7808-5479 0000-0003-1900-6974
Record's date: 2024-04-06
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1297824/full
Papper original source: Front Cardiovasc Med. 11
APA: Peiró ÓM; Delgado-Cornejo JR; Sánchez-Giménez R; del-Moral-Ronda V; Lal-Trehan N; Rocamora-Horrach M; Carrasquer A; Peraire J; Fort-Gallifa I; Bardaji (2024). Prevalence and prognostic implications of myocardial injury across different waves of COVID-19. Front Cardiovasc Med, 11(), -. DOI: 10.3389/fcvm.2024.1297824
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3389/fcvm.2024.1297824
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications