Articles producció científica> Ciències Mèdiques Bàsiques

Immunotherapy and radiotherapy for older patients with locally advanced rectal cancer unfit for surgery or decline surgery: a practical proposal by the International Geriatric Radiotherapy Group

  • Identification data

    Identifier: imarina:9364946
    Authors:
    Nguyen NPMohammadianpanah MSunMyint APage BRVinh-Hung VGorobets OArenas MMazibuko TGiap HVasileiou MDutheil FTuscano CKarlsson ULDahbi ZNatoli ELi EKim LOboite JOboite EBose SVuong T
    Abstract:
    The standard of care for locally advanced rectal cancer is total neoadjuvant therapy followed by surgical resection. Current evidence suggests that selected patients may be able to delay or avoid surgery without affecting survival rates if they achieve a complete clinical response (CCR). However, for older cancer patients who are too frail for surgery or decline the surgical procedure, local recurrence may lead to a deterioration of patient quality of life. Thus, for clinicians, a treatment algorithm which is well tolerated and may improve CCR in older and frail patients with rectal cancer may improve the potential for prolonged remission and potential cure. Recently, immunotherapy with check point inhibitors (CPI) is a promising treatment in selected patients with high expression of program death ligands receptor 1 (PD- L1). Radiotherapy may enhance PD-L1 expression in rectal cancer and may improve response rate to immunotherapy. We propose an algorithm combining immunotherapy and radiotherapy for older patients with locally advanced rectal cancer who are too frail for surgery or who decline surgery.
  • Others:

    Author, as appears in the article.: Nguyen NP; Mohammadianpanah M; SunMyint A; Page BR; Vinh-Hung V; Gorobets O; Arenas M; Mazibuko T; Giap H; Vasileiou M; Dutheil F; Tuscano C; Karlsson UL; Dahbi Z; Natoli E; Li E; Kim L; Oboite J; Oboite E; Bose S; Vuong T
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Arenas Prat, Meritxell
    Keywords: Cpi Locally advanced Older Radiotherapy Rectal cancer
    Abstract: The standard of care for locally advanced rectal cancer is total neoadjuvant therapy followed by surgical resection. Current evidence suggests that selected patients may be able to delay or avoid surgery without affecting survival rates if they achieve a complete clinical response (CCR). However, for older cancer patients who are too frail for surgery or decline the surgical procedure, local recurrence may lead to a deterioration of patient quality of life. Thus, for clinicians, a treatment algorithm which is well tolerated and may improve CCR in older and frail patients with rectal cancer may improve the potential for prolonged remission and potential cure. Recently, immunotherapy with check point inhibitors (CPI) is a promising treatment in selected patients with high expression of program death ligands receptor 1 (PD- L1). Radiotherapy may enhance PD-L1 expression in rectal cancer and may improve response rate to immunotherapy. We propose an algorithm combining immunotherapy and radiotherapy for older patients with locally advanced rectal cancer who are too frail for surgery or who decline surgery.
    Thematic Areas: Biotecnología Cancer research Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Interdisciplinar Medicina i Medicina ii Oncology Saúde coletiva
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: meritxell.arenas@urv.cat
    Author identifier: 0000-0003-0815-2570
    Record's date: 2024-03-23
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1325610/full
    Papper original source: Frontiers In Oncology. 14
    APA: Nguyen NP; Mohammadianpanah M; SunMyint A; Page BR; Vinh-Hung V; Gorobets O; Arenas M; Mazibuko T; Giap H; Vasileiou M; Dutheil F; Tuscano C; Karlsson (2024). Immunotherapy and radiotherapy for older patients with locally advanced rectal cancer unfit for surgery or decline surgery: a practical proposal by the International Geriatric Radiotherapy Group. Frontiers In Oncology, 14(), -. DOI: 10.3389/fonc.2024.1325610
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3389/fonc.2024.1325610
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Cancer Research,Oncology
    Cpi
    Locally advanced
    Older
    Radiotherapy
    Rectal cancer
    Biotecnología
    Cancer research
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Interdisciplinar
    Medicina i
    Medicina ii
    Oncology
    Saúde coletiva
  • Documents:

  • Cerca a google

    Search to google scholar