Author, as appears in the article.: Nguyen NP; Mohammadianpanah M; SunMyint A; Page BR; Vinh-Hung V; Gorobets O; Arenas M; Mazibuko T; Giap H; Vasileiou M; Dutheil F; Tuscano C; Karlsson UL; Dahbi Z; Natoli E; Li E; Kim L; Oboite J; Oboite E; Bose S; Vuong T
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Arenas Prat, Meritxell
Keywords: Cpi Locally advanced Older Radiotherapy Rectal cancer
Abstract: The standard of care for locally advanced rectal cancer is total neoadjuvant therapy followed by surgical resection. Current evidence suggests that selected patients may be able to delay or avoid surgery without affecting survival rates if they achieve a complete clinical response (CCR). However, for older cancer patients who are too frail for surgery or decline the surgical procedure, local recurrence may lead to a deterioration of patient quality of life. Thus, for clinicians, a treatment algorithm which is well tolerated and may improve CCR in older and frail patients with rectal cancer may improve the potential for prolonged remission and potential cure. Recently, immunotherapy with check point inhibitors (CPI) is a promising treatment in selected patients with high expression of program death ligands receptor 1 (PD- L1). Radiotherapy may enhance PD-L1 expression in rectal cancer and may improve response rate to immunotherapy. We propose an algorithm combining immunotherapy and radiotherapy for older patients with locally advanced rectal cancer who are too frail for surgery or who decline surgery.
Thematic Areas: Biotecnología Cancer research Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Interdisciplinar Medicina i Medicina ii Oncology Saúde coletiva
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: meritxell.arenas@urv.cat
Author identifier: 0000-0003-0815-2570
Record's date: 2024-03-23
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1325610/full
Papper original source: Frontiers In Oncology. 14
APA: Nguyen NP; Mohammadianpanah M; SunMyint A; Page BR; Vinh-Hung V; Gorobets O; Arenas M; Mazibuko T; Giap H; Vasileiou M; Dutheil F; Tuscano C; Karlsson (2024). Immunotherapy and radiotherapy for older patients with locally advanced rectal cancer unfit for surgery or decline surgery: a practical proposal by the International Geriatric Radiotherapy Group. Frontiers In Oncology, 14(), -. DOI: 10.3389/fonc.2024.1325610
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3389/fonc.2024.1325610
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV