Repositori URV

Identifier: imarina:9366129

Handle: https://hdl.handle.net/20.500.11797/imarina9366129

Authors:
Khoury NÁngeles Martínez MNishi SKÁngel Martínez-González MCorella DCastañer OAlfredo Martínez JAlonso-Gómez ÁMWärnberg JVioque JRomaguera DLópez-Miranda JEstruch RTinahones FJManuel Santos-Lozano JSerra-Majem LBueno-Cavanillas ATur JACinza Sanjurjo SPintó XJuan Gaforio JMatía-Martín PVidal JVázquez CDaimiel LRos ESayon-Orea CV Sorli JPérez-Vega KAGarcia-Rios AOrtiz-Díaz FGómez-Gracia EZulet MAChaplin ACasas RSalcedo-Bellido ITojal-Sierra LBernal-Lopez MRVazquez-Ruiz ZAsensio EMGoday APeña-Orihuela PJSignes-Pastor AJGarcia-Arellano AFitó MBabio NSalas-Salvadó J

Abstract:
Endocrine disruptors (EDs) have emerged as potential contributors to the development of type-2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food.To assess at baseline and after 1-year of follow-up associations between estimated dietary intake (DI) of PFOS, and glucose homeostasis parameters and body-mass-index (BMI) in a senior population of 4600 non-diabetic participants from the PREDIMED-plus study.Multivariable linear regression models were conducted to assess associations between baseline PFOS-DI at lower bound (LB) and upper bound (UB) established by the EFSA, glucose homeostasis parameters and BMI.Compared to those in the lowest tertile, participants in the highest tertile of baseline PFOS-DI in LB and UB showed higher levels of HbA1c [β-coefficient(CI)] [0.01 %(0.002 to 0.026), and [0.06 mg/dL(0.026 to 0.087), both p-trend ≤ 0.001], and fasting plasma glucose in the LB PFOS-DI [1.05 mg/dL(0.050 to 2.046),p-trend = 0.022]. Prospectively, a positive association between LB of PFOS-DI and BMI [0.06 kg/m2(0.014 to 0.106) per 1-SD increment of energy-adjusted PFOS-DI was shown. Participants in the top tertile showed an increase in HOMA-IR [0.06(0.016 to 0.097), p-trend = 0.005] compared to participants in the reference tertile after 1-year of follow-up.This is the first study to explore the association between DI of PFOS and glucose homeostasis. In this study, a high baseline DI of PFOS was associated with a higher levels of fasting plasma glucose and HbA1c and with an increase in HOMA-IR and BMI after 1-year of follow-up.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.