Author, as appears in the article.: Corominas-Teruel, Xavier; Bracco, Martina; Fibla, Montserrat; Segundo, Rosa Maria San; Villalobos-Llao, Marc; Gallea, Cecile; Beranger, Benoit; Toba, Monica; Valero-Cabre, Antoni; Colomina, Maria Teresa
Department: Psicologia
URV's Author/s: Colomina Fosch, Maria Teresa / Corominas Teruel, Xavier / Fibla Simó, Montserrat / San Segundo Mozo, Rosa María
Keywords: Upper extremity Treatment outcome Transcranial direct current stimulation Tool Tdcs Stroke rehabilitation Stroke Scale Recovery of function Randomized controlled trials as topic Randomized controlled trial Plasticity Oscillations Neurorehabilitation Network connectivity Neglect Infarction, middle cerebral artery Humans Excitability Electrical-stimulation Double-blind method Cognition Brain networks
Abstract: Background Focal brain lesions following a stroke of the middle cerebral artery induce large-scale network disarray with a potential to impact multiple cognitive and behavioral domains. Over the last 20 years, non-invasive brain neuromodulation via electrical (tCS) stimulation has shown promise to modulate motor deficits and contribute to recovery. However, weak, inconsistent, or at times heterogeneous outcomes using these techniques have also highlighted the need for novel strategies and the assessment of their efficacy in ad hoc controlled clinical trials. Methods We here present a double-blind, sham-controlled, single-center, randomized pilot clinical trial involving participants having suffered a unilateral middle cerebral artery (MCA) stroke resulting in motor paralysis of the contralateral upper limb. Patients will undergo a 10-day regime (5 days a week for 2 consecutive weeks) of a newly designed high-definition transcranial direct current stimulation (HD-tDCS) protocol. Clinical evaluations (e.g., Fugl Meyer, NIHSS), computer-based cognitive assessments (visuo-motor adaptation and AX-CPT attention tasks), and electroencephalography (resting-state and task- evoked EEG) will be carried out at 3 time points: (I) Baseline, (II) Post-tDCS, and (III) Follow-up. The study consists of a four-arm trial comparing the impact on motor recovery of three active anodal tDCS conditions: ipsilesional DLPFC tDCS, contralesional cerebellar tDCS or combined DLPFC + contralesional cerebellar tDCS, and a sham tDCS intervention. The Fugl-Meyer Assessment for the upper extremity (FMA-UE) is selected as the primary outcome measure to quantify motor recovery. In every stimulation session, participants will receive 20 min of high- density tDCS stimulation (HD-tDCS) (up to 0.63 mA/ cm(2)) with pi cm(2) electrodes. Electrode scalp positioning relative to the cortical surface (anodes and cathodes) and intensities are based on a biophysical optimization model of current distribution ensuring a 0.25 V/m impact at each of the chosen targets. Discussion Our trial will gauge the therapeutic potential of accumulative sessions of HD-tDCS to improve upper limb motor and cognitive dysfunctions presented by middle cerebral artery stroke patients. In parallel, we aim at characterizing changes in electroencephalographic (EEG) activity as biomarkers of clinical effects and at identifying potential interactions between tDCS impact and motor performance outcomes. Our work will enrich our mechanistic understanding on prefrontal and cerebellar contributions to motor function and its rehabilitation following brain damage.
Thematic Areas: Saúde coletiva Psicología Pharmacology (medical) Odontología Nutrição Medicine, research & experimental Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências ambientais Biotecnología Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: montserrat.fibla@urv.cat rosamaria.sansegundo@urv.cat xavier.corominas@estudiants.urv.cat mariateresa.colomina@urv.cat
Author identifier: 0000-0001-6278-9324 0000-0001-7420-2914 0000-0003-2469-2753 0000-0002-5619-4874
Record's date: 2024-09-28
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07680-8
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Trials. 24 (Suppl. 1): 783-
APA: Corominas-Teruel, Xavier; Bracco, Martina; Fibla, Montserrat; Segundo, Rosa Maria San; Villalobos-Llao, Marc; Gallea, Cecile; Beranger, Benoit; Toba, (2023). High-density transcranial direct current stimulation to improve upper limb motor function following stroke: study protocol for a double-blind randomized clinical trial targeting prefrontal and/or cerebellar cognitive contributions to voluntary motion. Trials, 24(Suppl. 1), 783-. DOI: 10.1186/s13063-023-07680-8
Article's DOI: 10.1186/s13063-023-07680-8
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV