Author, as appears in the article.: Shyam, S; García-Gavilán, JF; Paz-Graniel, I; Gaforio, JJ; Martínez-González, MA; Corella, D; Martínez, JA; Alonso-Gómez, AM; Warnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Sanchez, VM; Pinto, X; Matía-Martín, P; Vidal, J; Alcarria, MD; Daimiel, L; Ros, E; Fernandez-Aranda, F; Nishi, SK; Garcia-Regata, O; Araluce, RP; Asensio, EM; Castaner, O; Garcia-Rios, A; Oncina-Canovas, A; Bouzas, C; Zulet, MA; Rayo, E; Casas, R; Martin-Pelaez, S; Tojal-Sierra, L; Bernal-Lopez, MR; Carlos, S; Sorli, JV; Goday, A; Pena-Orihuela, PJ; Pastor-Morel, A; Eguaras, S; Zomeno, MD; Delgado-Rodriguez, M; Babio, N; Fito, M; Salas-Salvado, J
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Nishi, Stephanie Kimiko / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge / Shyam, Sangeetha
Keywords: Weight loss Sars-cov2 Prospective studies Predimed-plus Overweight Older adults Obesity Metabolic syndrome Mediterranean diet Male Life style Humans Female Diet, mediterranean Covid-19 Cardiovascular diseases Aged
Abstract: ObjectivesWe tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.DesignSecondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial.SettingCommunity-dwelling, free-living participants in PREDIMED-Plus trial.Participants6,874 Spanish older adults (55-75 years, 49% women) with overweight/obesity and metabolic syndrome.InterventionParticipants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations.MeasurementsCOVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk.ResultsOverall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)).ConclusionsThere was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/ obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Planejamento urbano e regional / demografia Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar Geriatrics and gerontology Geriatrics & gerontology General medicine Engenharias iii Enfermagem Educação física Educação Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: sangeetha.shyam@urv.cat jesusfrancisco.garcia@urv.cat stephanie.nishi@urv.cat indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-3204-6877 0000-0002-3204-6877 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S1279770724002112?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Nutrition Health & Aging. 27 (12): 1153-1161
APA: Shyam, S; García-Gavilán, JF; Paz-Graniel, I; Gaforio, JJ; Martínez-González, MA; Corella, D; Martínez, JA; Alonso-Gómez, AM; Warnberg, J; Vioque, J; (2023). Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial. Journal Of Nutrition Health & Aging, 27(12), 1153-1161. DOI: 10.1007/s12603-023-2044-4
Article's DOI: 10.1007/s12603-023-2044-4
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV