Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

ELIXIR and Toxicology: a community in development

  • Identification data

    Identifier: imarina:9369745
    Authors:
    Martens MStierum RSchymanski ELEvelo CTAalizadeh RAladjov HArturi KAudouze KBabica PBerka KBessems JBlaha LBolton EECases MDamalas DDave KDilger MExner TGeerke DPGrafström RGray AHancock JMHollert HJeliazkova NJennen DJourdan FKahlem PKlanova JKleinjans JKondic TKone BLynch IMaran UMartinez Cuesta SMénager HNeumann SNymark POberacher HRamirez NRemy SRocca-Serra PSalek RMSallach BSansone SASanz FSarimveis HSarntivijai SSchulze TSlobodnik JSpjuth OTedds JThomaidis NWeber RJMvan Westen GJPWheelock CEWilliams AJWitters HZdrazil BŽupanič AWillighagen EL
    Abstract:
    Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the linkage of various life science efforts around modern predictive toxicology, the establishment of a new ELIXIR Community is seen as instrumental. In the past few years, joint efforts, building on incidental overlap, have been piloted in the context of ELIXIR. For example, the EU-ToxRisk, diXa, HeCaToS, transQST, and the nanotoxicology community have worked with the ELIXIR TeSS, Bioschemas, and Compute Platforms and activities. In 2018, a core group of interested parties wrote a proposal, outlining a sketch of what this new ELIXIR Toxicology Community would look like. A recent workshop (held September 30th to October 1st, 2020) extended this into an ELIXIR Toxicology roadmap and a shortlist of limited investment-high gain collaborations to give body to this new community. This Whitepaper outlines the results of these efforts and defines our vision of the ELIXIR Toxicology Community and how it complements other ELIXIR activities.
  • Others:

    Author, as appears in the article.: Martens M; Stierum R; Schymanski EL; Evelo CT; Aalizadeh R; Aladjov H; Arturi K; Audouze K; Babica P; Berka K; Bessems J; Blaha L; Bolton EE; Cases M; Damalas D; Dave K; Dilger M; Exner T; Geerke DP; Grafström R; Gray A; Hancock JM; Hollert H; Jeliazkova N; Jennen D; Jourdan F; Kahlem P; Klanova J; Kleinjans J; Kondic T; Kone B; Lynch I; Maran U; Martinez Cuesta S; Ménager H; Neumann S; Nymark P; Oberacher H; Ramirez N; Remy S; Rocca-Serra P; Salek RM; Sallach B; Sansone SA; Sanz F; Sarimveis H; Sarntivijai S; Schulze T; Slobodnik J; Spjuth O; Tedds J; Thomaidis N; Weber RJM; van Westen GJP; Wheelock CE; Williams AJ; Witters H; Zdrazil B; Županič A; Willighagen EL
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Ramírez González, Noelia
    Keywords: Elixir Fair Interoperability Toxicology
    Abstract: Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the linkage of various life science efforts around modern predictive toxicology, the establishment of a new ELIXIR Community is seen as instrumental. In the past few years, joint efforts, building on incidental overlap, have been piloted in the context of ELIXIR. For example, the EU-ToxRisk, diXa, HeCaToS, transQST, and the nanotoxicology community have worked with the ELIXIR TeSS, Bioschemas, and Compute Platforms and activities. In 2018, a core group of interested parties wrote a proposal, outlining a sketch of what this new ELIXIR Toxicology Community would look like. A recent workshop (held September 30th to October 1st, 2020) extended this into an ELIXIR Toxicology roadmap and a shortlist of limited investment-high gain collaborations to give body to this new community. This Whitepaper outlines the results of these efforts and defines our vision of the ELIXIR Toxicology Community and how it complements other ELIXIR activities.
    Thematic Areas: Biochemistry, genetics and molecular biology (all) Biochemistry, genetics and molecular biology (miscellaneous) Biotecnología Ciência da computação Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Farmacia General biochemistry,genetics and molecular biology General immunology and microbiology General medicine General pharmacology, toxicology and pharmaceutics Immunology and microbiology (all) Immunology and microbiology (miscellaneous) Interdisciplinar Matemática / probabilidade e estatística Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (all) Medicine (miscellaneous) Pharmacology, toxicology and pharmaceutics (all) Pharmacology, toxicology and pharmaceutics (miscellaneous)
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: noelia.ramirez@urv.cat
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://f1000research.com/articles/10-1129/v2
    Papper original source: F1000research. 10
    APA: Martens M; Stierum R; Schymanski EL; Evelo CT; Aalizadeh R; Aladjov H; Arturi K; Audouze K; Babica P; Berka K; Bessems J; Blaha L; Bolton EE; Cases M; (2021). ELIXIR and Toxicology: a community in development. F1000research, 10(), -. DOI: 10.12688/f1000research.74502.2
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.12688/f1000research.74502.2
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Immunology and Microbiology (Miscellaneous),Medicine (Miscellaneous),Pharmacology, Toxicology and Pharmaceutics (Miscellaneous)
    Elixir
    Fair
    Interoperability
    Toxicology
    Biochemistry, genetics and molecular biology (all)
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biotecnología
    Ciência da computação
    Ciências agrárias i
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Economia
    Farmacia
    General biochemistry,genetics and molecular biology
    General immunology and microbiology
    General medicine
    General pharmacology, toxicology and pharmaceutics
    Immunology and microbiology (all)
    Immunology and microbiology (miscellaneous)
    Interdisciplinar
    Matemática / probabilidade e estatística
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Medicine (all)
    Medicine (miscellaneous)
    Pharmacology, toxicology and pharmaceutics (all)
    Pharmacology, toxicology and pharmaceutics (miscellaneous)
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