Articles producció científica> Bioquímica i Biotecnologia

Effect of 1-year lifestyle intervention with energy-reduced Mediterranean diet and physical activity promotion on the gut metabolome and microbiota: a randomized clinical trial

  • Identification data

    Identifier: imarina:9373512
    Authors:
    Garcia-Gavilan, Jesis FAtzeni, AlessandroBabio, NancyLiang, LimingBelzer, ClaraVioque, JesusCorella, DoloresFito, MontserratVidal, JosepMoreno-Indias, IsabelTorres-Collado, LauraColtell, OscarToledo, EstefaniaClish, ClaryHernando, JavierYun, HuanHernandez-Cacho, AdrianJeanfavre, SarahDennis, CourtneyGomez-Perez, Ana MMartinez, Maria AngelesRuiz-Canela, MiguelTinahones, Francisco JHu, Frank BSalas-Salvado, Jordi
    Abstract:
    Background: The health bene fi ts of the Mediterranean diet (MedDiet) have been linked to the presence of bene fi cial gut microbes and related metabolites. However, its impact on the fecal metabolome remains poorly understood. Objectives: Our goal was to investigate the weight-loss effects of a 1-y lifestyle intervention based on an energy-reduced MedDiet coupled with physical activity (intervention group), compared with an ad libitum MedDiet (control group), on fecal metabolites, fecal microbiota, and their potential association with cardiovascular disease risk factors. Methods: A total of 400 participants (200 from each study group), aged 55 - 75 y, and at high cardiovascular disease risk, were included. Dietary and lifestyle information, anthropometric measurements, blood biochemical parameters, and stool samples were collected at baseline and after 1 y of followup. Liquid chromatography-tandem mass spectrometry was used to pro fi le endogenous fecal metabolites, and 16S amplicon sequencing was employed to pro fi le the fecal microbiota. Results: Compared with the control group, the intervention group exhibited greater weight loss and improvement in various cardiovascular disease risk factors. We identi fi ed intervention effects on 4 stool metabolites and subnetworks primarily composed of bile acids, ceramides, and sphingosines, fatty acids, carnitines, nucleotides, and metabolites of purine and the Krebs cycle. Some of these were associated with changes in several cardiovascular disease risk factors. In addition, we observed a reduction in the abundance of the genera Eubacterium hallii group and Dorea , and an increase in alpha diversity in the intervention group after 1 y of follow-up. Changes in the intervention -related microbiota pro fi les were also associate
  • Others:

    Author, as appears in the article.: Garcia-Gavilan, Jesis F; Atzeni, Alessandro; Babio, Nancy; Liang, Liming; Belzer, Clara; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Josep; Moreno-Indias, Isabel; Torres-Collado, Laura; Coltell, Oscar; Toledo, Estefania; Clish, Clary; Hernando, Javier; Yun, Huan; Hernandez-Cacho, Adrian; Jeanfavre, Sarah; Dennis, Courtney; Gomez-Perez, Ana M; Martinez, Maria Angeles; Ruiz-Canela, Miguel; Tinahones, Francisco J; Hu, Frank B; Salas-Salvado, Jordi
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / HERNÁNDEZ CACHO, ADRIÁN / Martínez Rodríguez, María Ángeles / MARTÍNEZ VERA, MARÍA ASUNCIÓN / Salas Salvadó, Jorge
    Keywords: Sphingolipids Obesity Metabolic syndrome Mediterranean diet Lifestyle intervention Insulin-resistance Glucos Fecal microbiota Fecal metabolome Fecal metabolom Cholesterol Cardiovascular disease risk factor Cardiocascular risk factor Bile-acid Adherence
    Abstract: Background: The health bene fi ts of the Mediterranean diet (MedDiet) have been linked to the presence of bene fi cial gut microbes and related metabolites. However, its impact on the fecal metabolome remains poorly understood. Objectives: Our goal was to investigate the weight-loss effects of a 1-y lifestyle intervention based on an energy-reduced MedDiet coupled with physical activity (intervention group), compared with an ad libitum MedDiet (control group), on fecal metabolites, fecal microbiota, and their potential association with cardiovascular disease risk factors. Methods: A total of 400 participants (200 from each study group), aged 55 - 75 y, and at high cardiovascular disease risk, were included. Dietary and lifestyle information, anthropometric measurements, blood biochemical parameters, and stool samples were collected at baseline and after 1 y of followup. Liquid chromatography-tandem mass spectrometry was used to pro fi le endogenous fecal metabolites, and 16S amplicon sequencing was employed to pro fi le the fecal microbiota. Results: Compared with the control group, the intervention group exhibited greater weight loss and improvement in various cardiovascular disease risk factors. We identi fi ed intervention effects on 4 stool metabolites and subnetworks primarily composed of bile acids, ceramides, and sphingosines, fatty acids, carnitines, nucleotides, and metabolites of purine and the Krebs cycle. Some of these were associated with changes in several cardiovascular disease risk factors. In addition, we observed a reduction in the abundance of the genera Eubacterium hallii group and Dorea , and an increase in alpha diversity in the intervention group after 1 y of follow-up. Changes in the intervention -related microbiota pro fi les were also associated with alterations in different fecal metabolite subnetworks and some cardiovascular disease risk factors. Conclusions: An intervention based on an energy -reduced MedDiet and physical activity promotion, compared with an ad libitum MedDiet, was associated with improvements in cardiometabolic risk factors, potentially through modulation of the fecal microbiota and metabolome. This trial was registered at https://www.isrctn.com/ as ISRCTN89898870 (https://doi.org/10.1186/ISRCTN89898870).
    Thematic Areas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Enfermagem Educação física Ciências biológicas ii Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jesusfrancisco.garcia@urv.cat adrian.hernandez@urv.cat alessandro.atzeni@urv.cat mangeles.martinez@urv.cat jesusfrancisco.garcia@urv.cat alessandro.atzeni@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-1804-8606 0000-0001-8595-3772 0000-0002-1804-8606 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0002916524001679?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: American Journal Of Clinical Nutrition. 119 (5): 1143-1154
    APA: Garcia-Gavilan, Jesis F; Atzeni, Alessandro; Babio, Nancy; Liang, Liming; Belzer, Clara; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Jos (2024). Effect of 1-year lifestyle intervention with energy-reduced Mediterranean diet and physical activity promotion on the gut metabolome and microbiota: a randomized clinical trial. American Journal Of Clinical Nutrition, 119(5), 1143-1154. DOI: 10.1016/j.ajcnut.2024.02.021
    Article's DOI: 10.1016/j.ajcnut.2024.02.021
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Sphingolipids
    Obesity
    Metabolic syndrome
    Mediterranean diet
    Lifestyle intervention
    Insulin-resistance
    Glucos
    Fecal microbiota
    Fecal metabolome
    Fecal metabolom
    Cholesterol
    Cardiovascular disease risk factor
    Cardiocascular risk factor
    Bile-acid
    Adherence
    Serviço social
    Saúde coletiva
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Enfermagem
    Educação física
    Ciências biológicas ii
    Ciência de alimentos
    Biotecnología
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