Articles producció científica> Ciències Mèdiques Bàsiques

Involvement of extracellular vesicle-encapsulated miRNAs in human reproductive disorders: a systematic review.

  • Identification data

    Identifier: imarina:9378108
    Authors:
    Barranco ISalas-Huetos ABerlanga ASpinaci MYeste MRibas-Maynou J
    Abstract:
    In recent years, extracellular vesicles (EVs) have emerged as essential players in cell-to-cell communication, particularly having an active regulating role in biological systems. Because reproductive-associated processes are not exempt of this communication, multiple studies have been devoted to this realm, focusing on gamete maturation, embryo implantation or fetal development. The aim of the present review was to comprehensively and systematically collect evidence about the function of the microRNA (miRNA) encapsulated in EVs isolated from different reproductive tissues or fluids in reproductive-related diseases. Following PRISMA guidelines, we conducted a systematic search of the literature published in MEDLINE-PubMed until the end of February 2021. After selection, 32 studies were included in the qualitative review comparing the miRNA expression profile in EVs between different pathological disorders. Most reports showed the potential of the miRNAs carried by EVs to be used as putative biomarkers of reproductive disorders, including pregnancy affections, disease progression and quality of preimplantation embryos. The most relevant miRNAs were found to be highly heterogeneous among studies, with some conflicting results. Further research is thus warranted to address whether cofounding factors, such as the methods to isolate EVs and miRNAs, the subset of EVs, the criteria of patient selection, the timing of sample retrieval, or any other factor, may explain the inconsistencies between studies.
  • Others:

    Author, as appears in the article.: Barranco I; Salas-Huetos A; Berlanga A; Spinaci M; Yeste M; Ribas-Maynou J
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Salas Huetos, Albert
    Keywords: Blastocyst Cell communication Embryo implantation Extracellular vesicles Female Humans Micrornas Pregnancy
    Abstract: In recent years, extracellular vesicles (EVs) have emerged as essential players in cell-to-cell communication, particularly having an active regulating role in biological systems. Because reproductive-associated processes are not exempt of this communication, multiple studies have been devoted to this realm, focusing on gamete maturation, embryo implantation or fetal development. The aim of the present review was to comprehensively and systematically collect evidence about the function of the microRNA (miRNA) encapsulated in EVs isolated from different reproductive tissues or fluids in reproductive-related diseases. Following PRISMA guidelines, we conducted a systematic search of the literature published in MEDLINE-PubMed until the end of February 2021. After selection, 32 studies were included in the qualitative review comparing the miRNA expression profile in EVs between different pathological disorders. Most reports showed the potential of the miRNAs carried by EVs to be used as putative biomarkers of reproductive disorders, including pregnancy affections, disease progression and quality of preimplantation embryos. The most relevant miRNAs were found to be highly heterogeneous among studies, with some conflicting results. Further research is thus warranted to address whether cofounding factors, such as the methods to isolate EVs and miRNAs, the subset of EVs, the criteria of patient selection, the timing of sample retrieval, or any other factor, may explain the inconsistencies between studies.
    Thematic Areas: Animal science and zoology Biodiversidade Biotechnology Biotecnología Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Developmental biology Endocrinology Farmacia Genetics Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (all) Molecular biology Odontología Psicología Química Reproductive biology Reproductive medicine Zoology Zootecnia / recursos pesqueiros
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: albert.salas@urv.cat
    Author identifier: 0000-0001-5914-6862
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.publish.csiro.au/RD/RD21301
    Papper original source: Reproduction Fertility And Development. 34 (11): 751-775
    APA: Barranco I; Salas-Huetos A; Berlanga A; Spinaci M; Yeste M; Ribas-Maynou J (2022). Involvement of extracellular vesicle-encapsulated miRNAs in human reproductive disorders: a systematic review.. Reproduction Fertility And Development, 34(11), 751-775. DOI: 10.1071/RD21301
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1071/RD21301
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Animal Science and Zoology,Biotechnology,Developmental Biology,Endocrinology,Genetics,Molecular Biology,Reproductive Biology,Reproductive Medicine,Zoology
    Blastocyst
    Cell communication
    Embryo implantation
    Extracellular vesicles
    Female
    Humans
    Micrornas
    Pregnancy
    Animal science and zoology
    Biodiversidade
    Biotechnology
    Biotecnología
    Ciências agrárias i
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Developmental biology
    Endocrinology
    Farmacia
    Genetics
    Interdisciplinar
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Medicine (all)
    Molecular biology
    Odontología
    Psicología
    Química
    Reproductive biology
    Reproductive medicine
    Zoology
    Zootecnia / recursos pesqueiros
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