Author, as appears in the article.: Guerrini, C; Escribano, J; Ramírez, N; Vinaixa, M; Sunyer-Caldú, A; Gil-Solsona, R; Gago-Ferrero, P
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Ramírez González, Noelia / Vinaixa Crevillent, Maria
Keywords: Wide-scope screening Suspect screening analysis Suspect screening analysi Suspect Substances Non-targeted analysis Metabolites Human exposure High-resolution mass spectrometry Health Exposomics Environmental chemicals Early-life Current knowledge Contaminants Chemical exposome Challeng Biomarkers
Abstract: Exposure to organic compounds during early-life stages can disrupt human development and increase susceptibility to adverse health outcomes later in life. Despite evidence of these impacts, research has primarily focused on targeted analyses, missing the complex nature of early-life exposures. Comprehensive approaches are needed to better characterize these complex mixtures. Recent advances in high-resolution mass spectrometry and computational science have enabled the comprehensive analysis of numerous chemicals through wide-scope screening approaches, yet their application in early-life exposome studies is still limited. This review critically examines studies from the past decade using wide-scope screening to investigate the early-life chemical exposome, emphasizing organic compounds. It evaluates each step of the analytical workflow, including sample collection, preparation, analysis, and data processing, and concludes with recommendations for future research to improve understanding of the early-life chemical exposome and its health implications.
Thematic Areas: Spectroscopy Química Medicina ii Interdisciplinar Farmacia Environmental chemistry Engenharias iv Engenharias iii Engenharias ii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Astronomia / física Analytical chemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: maria.vinaixa@urv.cat
Author identifier: 0000-0001-9804-0171
Record's date: 2024-09-14
Papper version: info:eu-repo/semantics/publishedVersion
Papper original source: Trac-Trends In Analytical Chemistry. 180 117903-
APA: Guerrini, C; Escribano, J; Ramírez, N; Vinaixa, M; Sunyer-Caldú, A; Gil-Solsona, R; Gago-Ferrero, P (2024). Early-life chemical exposome: Comprehensive strategies for wide-scope screening of organic compounds. Trac-Trends In Analytical Chemistry, 180(), 117903-. DOI: 10.1016/j.trac.2024.117903
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV