Long-term association between water intake and kidney function in a population at high cardiovascular risk

Identifier:  imarina:9391490

Handle: https://hdl.handle.net/20.500.11797/imarina9391490

Authors:  Paz-Graniel, Indira; Valle-Hita, Cristina; Babio, Nancy; Serra-Majem, Lluis; Vioque, Jesus; Zomeno, Maria Dolores; Corella, Dolores; Pinto, Xavier; Cano-Ibanez, Naomi; Tur, Josep A; Cuadrado-Soto, Esther; Martinez, J A; Diaz-Lopez, Andres; Torres-Collado, Laura; Goday, Albert; Fernandez-Carrion, Rebeca; Nissenshon, Mariela; Riera-Mestre, Antoni; Garrido-Garrido, Eva; Bouzas, Cristina; Abete, Itziar; Daimiel, Lidia; Cornejo-Pareja, Isabel; Vazquez-Ruiz, Zenaida; Khoury, Nadine; Perez-Vega, Karla Alejandra; Salas-Salvado, Jordi

Abstract:
Objectives: The evidence on water intake in the prevention of kidney function decline is scarce at population level in well-being individuals at high cardiovascular risk. Therefore, we aimed to longitudinally evaluate the associations between total water intake and subtypes and kidney function, through estimated-Glomerular Filtration Rate (eGFR). Methods: Three-year prospective analysis conducted in 1986 older adults (aged 55-75 year) with overweight/ obesity and metabolic syndrome from the PREDIMED-Plus study. Water intake was assessed using validated beverage and food frequency questionnaires. Serum creatinine-based eGFR (SCr-based eGFR; ml/min/1.73 m2) was estimated using the CKD-EPI equation at baseline, one-year and 3-years of follow-up. Mixed-effects linear regression models were fitted to evaluate the associations between baseline total water intake and subtypes, and SCr-based eGFR over 3-years of follow-up. Results: Participants in the highest baseline tertile of total water intake, plain water and water from all fluids showed a lower decrease in SCr-based eGFR after 3-years of follow-up, compared to those in the lowest tertile. Participants with the highest tap water consumption showed a lower SCr-based eGFR decline after 1-year and 3-years of followup, in comparerd to participants in the lowest intake category (T3 vs. T1: (3 : 1.4 ml/min/1.73 m2; 95%CI: 0.5-2.3, (3 : 1.0; 95%CI: 0.1-2.0, respectively). Conclusions: Plain water rather than other water sources, and especially tap water, was associated with lower kidney function decline assessed through eGFR over 3-years of follow-up, in older individuals at high cardiovascular risk. Trial registration: ISRCTN89898870. Retrospectively registered on 24 July 2014 (c) 2024 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).