Articles producció científica> Bioquímica i Biotecnologia

Parent-child microbiota relationships involved in childhood obesity: A CORALS ancillary study

  • Identification data

    Identifier: imarina:9393159
    Authors:
    de Cuevillas, BegonaRiezu-Boj, Jose IMilagro, Fermin IAlquegui, Sergio GaleraBabio, NancyPastor-Villaescusa, BelenGil-Campos, MercedesLeis, RosauraDe Miguel-Etayo, PilarMoreno, Luis ASalas-Salvado, JordiMartinez, J AlfredoNavas-Carretero, Santiago
    Abstract:
    Objectives: Childhood obesity continues to rise worldwide. Family gut microorganisms may be associated with childhood obesity. The aim of the study was to analyze bacterial similarities in fecal microbiota composition between parent-offspring pairs as linked to body weight. Methods: A total of 146 father/mother and offspring pairs were categorized into four groups according to the weight status of the parent-child pair as follows: group 1, parent and child with normal weight; group 2, parent and child with overweight/obesity; group 3, parent with normal weight and child with overweight/ obesity; group 4, parent with overweight/obesity and child with normal weight. Anthropometric measurements and lifestyle assessments were performed in all participants. Microbiota characteristics were determined by 16S ribosomal RNA gene sequencing. Logistic regression models were performed to determine whether the abundance of any bacteria was able to predict childhood obesity. Moreover, receiver operating characteristic curves were fitted to define the relative diagnostic strength of bacterial taxa for the correct identification of childhood obesity. Results: The absence/abundance of Catenibacterium mitsuokai, Prevotella stercorea, Desulfovibrio piger, Massiliprevotella massiliensis, and Phascolarctobacterium succinatutens was involved in body weight family associations. A positive relationship between P. succinatutens richness from parents and M. massiliensis from children was observed with regard to body weight status (odds ratio, 1.14, P = 0.013). Conclusions: This study describes five potential gut bacteria that may be putatively involved in family weight status relationships and appear to be useful for predicting obesity. (c) 2024 The Author(s). Published by Elsevier Inc. This is
  • Others:

    Author, as appears in the article.: de Cuevillas, Begona; Riezu-Boj, Jose I; Milagro, Fermin I; Alquegui, Sergio Galera; Babio, Nancy; Pastor-Villaescusa, Belen; Gil-Campos, Mercedes; Leis, Rosaura; De Miguel-Etayo, Pilar; Moreno, Luis A; Salas-Salvado, Jordi; Martinez, J Alfredo; Navas-Carretero, Santiago
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
    Keywords: Rna, ribosomal, 16s Prevotella Plasma Pediatric obesity Parents Offspring Microbiota Male Logistic models Lifestyle factors Lifestyle factor Humans Gut Glucose Genetics Gastrointestinal microbiome Female Feces Die Desulfovibrio Childhood obesity Child Body weight Bacteria Adult
    Abstract: Objectives: Childhood obesity continues to rise worldwide. Family gut microorganisms may be associated with childhood obesity. The aim of the study was to analyze bacterial similarities in fecal microbiota composition between parent-offspring pairs as linked to body weight. Methods: A total of 146 father/mother and offspring pairs were categorized into four groups according to the weight status of the parent-child pair as follows: group 1, parent and child with normal weight; group 2, parent and child with overweight/obesity; group 3, parent with normal weight and child with overweight/ obesity; group 4, parent with overweight/obesity and child with normal weight. Anthropometric measurements and lifestyle assessments were performed in all participants. Microbiota characteristics were determined by 16S ribosomal RNA gene sequencing. Logistic regression models were performed to determine whether the abundance of any bacteria was able to predict childhood obesity. Moreover, receiver operating characteristic curves were fitted to define the relative diagnostic strength of bacterial taxa for the correct identification of childhood obesity. Results: The absence/abundance of Catenibacterium mitsuokai, Prevotella stercorea, Desulfovibrio piger, Massiliprevotella massiliensis, and Phascolarctobacterium succinatutens was involved in body weight family associations. A positive relationship between P. succinatutens richness from parents and M. massiliensis from children was observed with regard to body weight status (odds ratio, 1.14, P = 0.013). Conclusions: This study describes five potential gut bacteria that may be putatively involved in family weight status relationships and appear to be useful for predicting obesity. (c) 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
    Thematic Areas: Serviço social Saúde coletiva Química Psicología Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Endocrinology, diabetes and metabolism Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física Arquitetura, urbanismo e design
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2025-02-19
    Paper version: info:eu-repo/semantics/publishedVersion
    Paper original source: Nutrition. 130 112603-
    APA: de Cuevillas, Begona; Riezu-Boj, Jose I; Milagro, Fermin I; Alquegui, Sergio Galera; Babio, Nancy; Pastor-Villaescusa, Belen; Gil-Campos, Mercedes; Le (2025). Parent-child microbiota relationships involved in childhood obesity: A CORALS ancillary study. Nutrition, 130(), 112603-. DOI: 10.1016/j.nut.2024.112603
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2025
    Publication Type: Journal Publications
  • Keywords:

    Endocrinology, Diabetes and Metabolism,Nutrition & Dietetics,Nutrition and Dietetics
    Rna, ribosomal, 16s
    Prevotella
    Plasma
    Pediatric obesity
    Parents
    Offspring
    Microbiota
    Male
    Logistic models
    Lifestyle factors
    Lifestyle factor
    Humans
    Gut
    Glucose
    Genetics
    Gastrointestinal microbiome
    Female
    Feces
    Die
    Desulfovibrio
    Childhood obesity
    Child
    Body weight
    Bacteria
    Adult
    Serviço social
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iii
    Engenharias ii
    Enfermagem
    Endocrinology, diabetes and metabolism
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
    Arquitetura, urbanismo e design
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