Articles producció científica> Bioquímica i Biotecnologia

Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial

  • Identification data

    Identifier: imarina:9411315
    Authors:
    Dominguez-Lopez, InesLamuela-Raventos, Rosa MRazquin, CristinaArancibia-Riveros, CamilaGalkina, PolinaSalas-Salvado, JordiAlonso-Gomez, Angel MFito, MontserratFiol, MiquelLapetra, JoseGomez-Gracia, EnriqueSorli, Jose VRuiz-Canela, MiguelCastaner, OlgaLiang, LimingSerra-Majem, LluisHu, Frank BRos, EmilioMartinez-Gonzalez, Miguel angelEstruch, Ramon
    Abstract:
    Background and Aims Moderate wine consumption has been associated with lower cardiovascular disease (CVD) risk in older populations. However, wine consumption information through self-reports is prone to measurement errors inherent to subjective assessments. The aim of this study was to evaluate the association between urinary tartaric acid, an objective biomarker of wine consumption, and the rate of a composite clinical CVD event.Methods A case-cohort nested study was designed within the PREDIMED trial with 1232 participants: 685 incident cases of CVD and a random subcohort of 625 participants (including 78 overlapping cases). Wine consumption was registered using validated food frequency questionnaires. Liquid chromatography-tandem mass spectrometry was used to measure urinary tartaric acid at baseline and after one year of intervention. Weighted Cox regression models were used to estimate hazard ratios (HRs) of CVD.Results Tartaric acid was correlated with self-reported wine consumption at baseline [r = 0.46 (95% CI 0.41; 0.50)]. Five categories of post hoc urinary tartaric acid excretion were used for better representation of risk patterns. Concentrations of 3-12 and 12-35 mu g/mL, which reflect similar to 3-12 and 12-35 glasses/month of wine, were associated with lower CVD risk [HR 0.62 (95% CI 0.38; 1.00), P = .050 and HR 0.50 (95% CI 0.27; 0.95), P = .035, respectively]. Less significant associations between self-reported wine consumption and CVD risk were observed.Conclusions Light-to-moderate wine consumption, measured through an objective biomarker (tartaric acid), was prospectively associated with lower CVD rate in a Mediterranean population at high cardiovascular risk.
  • Others:

    Author, as appears in the article.: Dominguez-Lopez, Ines; Lamuela-Raventos, Rosa M; Razquin, Cristina; Arancibia-Riveros, Camila; Galkina, Polina; Salas-Salvado, Jordi; Alonso-Gomez, Angel M; Fito, Montserrat; Fiol, Miquel; Lapetra, Jose; Gomez-Gracia, Enrique; Sorli, Jose V; Ruiz-Canela, Miguel; Castaner, Olga; Liang, Liming; Serra-Majem, Lluis; Hu, Frank B; Ros, Emilio; Martinez-Gonzalez, Miguel angel; Estruch, Ramon
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Wome Wine Tartrates Tartaric acid Red wine Polyphenol intake Myocardial-infarction Mortality Middle aged Mediterranean diet Mediterranean die Male Lipids Humans Heart disease risk factors Follow-up Female Coronary-heart-disease Cardiovascular diseases Cardiovascular disease Biomarkers Biomarker Alcohol-consumption Alcohol drinking Aged
    Abstract: Background and Aims Moderate wine consumption has been associated with lower cardiovascular disease (CVD) risk in older populations. However, wine consumption information through self-reports is prone to measurement errors inherent to subjective assessments. The aim of this study was to evaluate the association between urinary tartaric acid, an objective biomarker of wine consumption, and the rate of a composite clinical CVD event.Methods A case-cohort nested study was designed within the PREDIMED trial with 1232 participants: 685 incident cases of CVD and a random subcohort of 625 participants (including 78 overlapping cases). Wine consumption was registered using validated food frequency questionnaires. Liquid chromatography-tandem mass spectrometry was used to measure urinary tartaric acid at baseline and after one year of intervention. Weighted Cox regression models were used to estimate hazard ratios (HRs) of CVD.Results Tartaric acid was correlated with self-reported wine consumption at baseline [r = 0.46 (95% CI 0.41; 0.50)]. Five categories of post hoc urinary tartaric acid excretion were used for better representation of risk patterns. Concentrations of 3-12 and 12-35 mu g/mL, which reflect similar to 3-12 and 12-35 glasses/month of wine, were associated with lower CVD risk [HR 0.62 (95% CI 0.38; 1.00), P = .050 and HR 0.50 (95% CI 0.27; 0.95), P = .035, respectively]. Less significant associations between self-reported wine consumption and CVD risk were observed.Conclusions Light-to-moderate wine consumption, measured through an objective biomarker (tartaric acid), was prospectively associated with lower CVD rate in a Mediterranean population at high cardiovascular risk.
    Thematic Areas: Saúde coletiva Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Direito Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2025-02-18
    Paper version: info:eu-repo/semantics/publishedVersion
    Paper original source: European Heart Journal. 46 (2): 161-172
    APA: Dominguez-Lopez, Ines; Lamuela-Raventos, Rosa M; Razquin, Cristina; Arancibia-Riveros, Camila; Galkina, Polina; Salas-Salvado, Jordi; Alonso-Gomez, An (2025). Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial. European Heart Journal, 46(2), 161-172. DOI: 10.1093/eurheartj/ehae804
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2025
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Wome
    Wine
    Tartrates
    Tartaric acid
    Red wine
    Polyphenol intake
    Myocardial-infarction
    Mortality
    Middle aged
    Mediterranean diet
    Mediterranean die
    Male
    Lipids
    Humans
    Heart disease risk factors
    Follow-up
    Female
    Coronary-heart-disease
    Cardiovascular diseases
    Cardiovascular disease
    Biomarkers
    Biomarker
    Alcohol-consumption
    Alcohol drinking
    Aged
    Saúde coletiva
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Educação física
    Direito
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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