Author, as appears in the article.: Dominguez-Lopez, Ines; Lamuela-Raventos, Rosa M; Razquin, Cristina; Arancibia-Riveros, Camila; Galkina, Polina; Salas-Salvado, Jordi; Alonso-Gomez, Angel M; Fito, Montserrat; Fiol, Miquel; Lapetra, Jose; Gomez-Gracia, Enrique; Sorli, Jose V; Ruiz-Canela, Miguel; Castaner, Olga; Liang, Liming; Serra-Majem, Lluis; Hu, Frank B; Ros, Emilio; Martinez-Gonzalez, Miguel angel; Estruch, Ramon
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Wome Wine Tartrates Tartaric acid Red wine Polyphenol intake Myocardial-infarction Mortality Middle aged Mediterranean diet Mediterranean die Male Lipids Humans Heart disease risk factors Follow-up Female Coronary-heart-disease Cardiovascular diseases Cardiovascular disease Biomarkers Biomarker Alcohol-consumption Alcohol drinking Aged
Abstract: Background and Aims Moderate wine consumption has been associated with lower cardiovascular disease (CVD) risk in older populations. However, wine consumption information through self-reports is prone to measurement errors inherent to subjective assessments. The aim of this study was to evaluate the association between urinary tartaric acid, an objective biomarker of wine consumption, and the rate of a composite clinical CVD event.Methods A case-cohort nested study was designed within the PREDIMED trial with 1232 participants: 685 incident cases of CVD and a random subcohort of 625 participants (including 78 overlapping cases). Wine consumption was registered using validated food frequency questionnaires. Liquid chromatography-tandem mass spectrometry was used to measure urinary tartaric acid at baseline and after one year of intervention. Weighted Cox regression models were used to estimate hazard ratios (HRs) of CVD.Results Tartaric acid was correlated with self-reported wine consumption at baseline [r = 0.46 (95% CI 0.41; 0.50)]. Five categories of post hoc urinary tartaric acid excretion were used for better representation of risk patterns. Concentrations of 3-12 and 12-35 mu g/mL, which reflect similar to 3-12 and 12-35 glasses/month of wine, were associated with lower CVD risk [HR 0.62 (95% CI 0.38; 1.00), P = .050 and HR 0.50 (95% CI 0.27; 0.95), P = .035, respectively]. Less significant associations between self-reported wine consumption and CVD risk were observed.Conclusions Light-to-moderate wine consumption, measured through an objective biomarker (tartaric acid), was prospectively associated with lower CVD rate in a Mediterranean population at high cardiovascular risk.
Thematic Areas: Saúde coletiva Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Direito Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/publishedVersion
Paper original source: European Heart Journal. 46 (2): 161-172
APA: Dominguez-Lopez, Ines; Lamuela-Raventos, Rosa M; Razquin, Cristina; Arancibia-Riveros, Camila; Galkina, Polina; Salas-Salvado, Jordi; Alonso-Gomez, An (2025). Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial. European Heart Journal, 46(2), 161-172. DOI: 10.1093/eurheartj/ehae804
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2025
Publication Type: Journal Publications