Association between dietary intake estimated levels of PCDD/Fs and human sperm quality

Identifier:  imarina:9443139

Handle: https://hdl.handle.net/20.500.11797/imarina9443139

Authors:  Martinez, Maria Angeles; Salas-Huetos, Albert; de la Puente, Maria Fernandez; Valle-Hita, Cristina; Khoury, Nadine; Sanchez-Resino, Elena; Ramos-Rodriguez, Carla; Davila-Cordova, Estefania; Salas-Salvado, Jordi; Babio, Nancy

Abstract:
This study aimed to investigate the association between estimated dietary intake of polychlorinated dibenzo-pdioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) and human sperm quality. This study crosssectionally assessed the associations between estimated dietary intake of PCDD/Fs and sperm quality parameters in 200 participants aged 18-40 years from the Led-Fertyl study. Linear regression models, accounting for potential confounding variables, were employed to evaluate the relationships. To estimate the PCDD/Fs exposure, food frequency questionnaires and the latest data on PCDD/Fs concentrations in food, primarily from Spanish sources, were used. Our findings indicate that, in comparison to participants in the lowest tertile, those in the highest tertile (T3) of PCDD/Fs dietary intake exhibited significantly elevated body mass index, increased consumption of meat, fish and eggs, and decreased consumption of nuts. Furthermore, individuals in T3 demonstrated a higher percentage of sperm head abnormalities (4.65 % [0.10; 9.24]; p-trend= 0.037) and a corresponding increase per 1-SD increment in energy-adjusted total PCDD/Fs dietary intake (1.84 % [0.38; 3.68]). No significant associations for other sperm parameters were found. Minimal research exists on PCDD/F dietary exposure and human sperm quality. This study shows significant direct association between higher PCDD/Fs intake and the percentage of sperm head abnormalities which potentially may compromise human reproductive health.