Articles producció científica> Ciències Mèdiques Bàsiques

Association between dietary intake estimated levels of PCDD/Fs and human sperm quality

  • Identification data

    Identifier: imarina:9443139
    Authors:
    Martinez, Maria AngelesSalas-Huetos, Albertde la Puente, Maria FernandezValle-Hita, CristinaKhoury, NadineSanchez-Resino, ElenaRamos-Rodriguez, CarlaDavila-Cordova, EstefaniaSalas-Salvado, JordiBabio, Nancy
    Abstract:
    This study aimed to investigate the association between estimated dietary intake of polychlorinated dibenzo-pdioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) and human sperm quality. This study crosssectionally assessed the associations between estimated dietary intake of PCDD/Fs and sperm quality parameters in 200 participants aged 18-40 years from the Led-Fertyl study. Linear regression models, accounting for potential confounding variables, were employed to evaluate the relationships. To estimate the PCDD/Fs exposure, food frequency questionnaires and the latest data on PCDD/Fs concentrations in food, primarily from Spanish sources, were used. Our findings indicate that, in comparison to participants in the lowest tertile, those in the highest tertile (T3) of PCDD/Fs dietary intake exhibited significantly elevated body mass index, increased consumption of meat, fish and eggs, and decreased consumption of nuts. Furthermore, individuals in T3 demonstrated a higher percentage of sperm head abnormalities (4.65 % [0.10; 9.24]; p-trend= 0.037) and a corresponding increase per 1-SD increment in energy-adjusted total PCDD/Fs dietary intake (1.84 % [0.38; 3.68]). No significant associations for other sperm parameters were found. Minimal research exists on PCDD/F dietary exposure and human sperm quality. This study shows significant direct association between higher PCDD/Fs intake and the percentage of sperm head abnormalities which potentially may compromise human reproductive health.
  • Others:

    Author, as appears in the article.: Martinez, Maria Angeles; Salas-Huetos, Albert; de la Puente, Maria Fernandez; Valle-Hita, Cristina; Khoury, Nadine; Sanchez-Resino, Elena; Ramos-Rodriguez, Carla; Davila-Cordova, Estefania; Salas-Salvado, Jordi; Babio, Nancy
    Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
    URV's Author/s: Babio Sánchez, Nancy Elvira / Martínez Rodríguez, María Ángeles / Salas Huetos, Albert / Salas Salvadó, Jorge
    Keywords: Sperm quality Populatio Polychlorinated dibenzo-p-furans (pcdd/fs) Morphology Infertility Food intake Food intak Food Fertilization Exposure Endocrine-disrupting chemicals Endocrine disrupting chemicals (edcs) Dioxin-like pcbs
    Abstract: This study aimed to investigate the association between estimated dietary intake of polychlorinated dibenzo-pdioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) and human sperm quality. This study crosssectionally assessed the associations between estimated dietary intake of PCDD/Fs and sperm quality parameters in 200 participants aged 18-40 years from the Led-Fertyl study. Linear regression models, accounting for potential confounding variables, were employed to evaluate the relationships. To estimate the PCDD/Fs exposure, food frequency questionnaires and the latest data on PCDD/Fs concentrations in food, primarily from Spanish sources, were used. Our findings indicate that, in comparison to participants in the lowest tertile, those in the highest tertile (T3) of PCDD/Fs dietary intake exhibited significantly elevated body mass index, increased consumption of meat, fish and eggs, and decreased consumption of nuts. Furthermore, individuals in T3 demonstrated a higher percentage of sperm head abnormalities (4.65 % [0.10; 9.24]; p-trend= 0.037) and a corresponding increase per 1-SD increment in energy-adjusted total PCDD/Fs dietary intake (1.84 % [0.38; 3.68]). No significant associations for other sperm parameters were found. Minimal research exists on PCDD/F dietary exposure and human sperm quality. This study shows significant direct association between higher PCDD/Fs intake and the percentage of sperm head abnormalities which potentially may compromise human reproductive health.
    Thematic Areas: Zootecnia / recursos pesqueiros Toxicology Saúde coletiva Reproductive biology Química Psicología Odontología Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências Farmacia Ensino Engenharias iii Engenharias i Ciências biológicas ii Ciências biológicas i Ciências ambientais Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: albert.salas@urv.cat mangeles.martinez@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0001-5914-6862 0000-0001-8595-3772 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2025-03-22
    Paper version: info:eu-repo/semantics/publishedVersion
    Paper original source: Reproductive Toxicology. 132 108831-
    APA: Martinez, Maria Angeles; Salas-Huetos, Albert; de la Puente, Maria Fernandez; Valle-Hita, Cristina; Khoury, Nadine; Sanchez-Resino, Elena; Ramos-Rodri (2025). Association between dietary intake estimated levels of PCDD/Fs and human sperm quality. Reproductive Toxicology, 132(), 108831-. DOI: 10.1016/j.reprotox.2025.108831
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2025
    Publication Type: Journal Publications
  • Keywords:

    Reproductive Biology,Toxicology
    Sperm quality
    Populatio
    Polychlorinated dibenzo-p-furans (pcdd/fs)
    Morphology
    Infertility
    Food intake
    Food intak
    Food
    Fertilization
    Exposure
    Endocrine-disrupting chemicals
    Endocrine disrupting chemicals (edcs)
    Dioxin-like pcbs
    Zootecnia / recursos pesqueiros
    Toxicology
    Saúde coletiva
    Reproductive biology
    Química
    Psicología
    Odontología
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    Farmacia
    Ensino
    Engenharias iii
    Engenharias i
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Biotecnología
    Biodiversidade
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