Author, as appears in the article.: Jurek, Joanna Michalina; Zablocka-Sowinska, Katarzyna; Mestres, Helena Clavero; Gutierrez, Leyre Reyes; Camaron, Javier; Auguet, Teresa
Department: Medicina i Cirurgia
URV's Author/s: Auguet Quintillà, Maria Teresa
Keywords: Adherence Adult Adults Comorbidity Dash diet Diabetes mellitus, type 2 Diet, mediterranean Dietary intervention Fasting Fatty liver Female Humans Male Masld/non-alcoholic fatty liver disease Mediterranean Mediterranean diet Metabolic outcomes Metabolic syndrome Middle aged Non-alcoholic fatty liver disease Obesity Randomized controlled trials as topic Ris Systematic revie Systematic review Type 2 diabetes Weight
Abstract: Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a public health concern, linked with immune-metabolic dysfunction. While lifestyle and dietary modifications remain the cornerstone of MASLD management, the optimal dietary approach remains uncertain. Objectives: This systematic review aims to investigate the impact of model dietary patterns on metabolic outcomes in patients with MASLD and evaluate their effects in individuals with coexisting metabolic conditions, such as obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). Methods: To conduct the review, PubMed, Scopus, Google Scholar, Cochrane CENTRAL, and ClinicalTrials.gov databases were searched for Randomized Controlled Trials (RCTs) on the adult population, published between January 2019 and September 2024, following PRISMA principles. The quality of the included RCTs was assessed qualitatively based on study characteristics. Results: The main findings of this review demonstrated that the use of interventions with dietary model based on Mediterranean diet (MED) and intermittent fasting (IF) approaches, such as alternative-day fasting (ADF) and time-restricted feeding regimens (TRF) may have potential in reducing body weight, BMI, and waist circumference, with additional benefits of improving glycemic control and reducing inflammation. The effects on hepatic functions, although limited, may be linked with reduced enzyme activity and liver stiffness. Additionally, the use of lacto-ovo-vegetarian diet (LOV-D) and the Dietary Approaches to Stop Hypertension (DASH) diet may offer additional health benefits, including blood pressure management. Conclusions: This review suggests that MED and IF-based strategies may reduce BW, improve glycemic control, and lower inflammation, with potential benefits for hepatic function. Further long-term studies are needed to confirm these effects and underlying mechanisms, which will allow for the optimization of protocols and ensure their safety in MASLD.
Research group: GRUP D'ESTUDI DE MALALTIES METABÒLIQUES ASSOCIADES A INSULINRESISTÈNCIA
Thematic Areas: Biotecnología Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Enfermagem Engenharias ii Engenharias iv Farmacia Food science Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Nutrição Nutrition & dietetics Nutrition and dietetics Planejamento urbano e regional / demografia Psicología Química Saúde coletiva Zootecnia / recursos pesqueiros
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: mariateresa.auguet@urv.cat
Author identifier: 0000-0003-0396-6428 https://orcid.org/0000-0003-0396-6428
Record's date: 2025-04-30
Paper version: info:eu-repo/semantics/publishedVersion
Paper original source: Nutrients. 17 (7): 1257-
APA: Jurek, Joanna Michalina; Zablocka-Sowinska, Katarzyna; Mestres, Helena Clavero; Gutierrez, Leyre Reyes; Camaron, Javier; Auguet, Teresa (2025). The Impact of Dietary Interventions on Metabolic Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Comorbid Conditions, Including Obesity and Type 2 Diabetes. Nutrients, 17(7), 1257-. DOI: 10.3390/nu17071257
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2025
Publication Type: Journal Publications
Repositori URV