Articles producció científica> Medicina i Cirurgia

Differential absorption and metabolism of hydroxytyrosol and its precursors oleuropein and secoiridoids

  • Datos identificativos

    Identificador: PC:1451
    Autores:
    López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M. Carme PiñolAlba MaciàMaría-Paz RomeroRosa SolàLaura RubióMaria-José Motilva
    Resumen:
    This study investigated and compared the absorption, metabolism, and subsequently, the tissue distribution and excretion of hydroxytyrosol (HT) administered either in its free form or through its naturally occurring esterified precursors, namely oleuropein (OLE) and its aglycone forms known as secoiridoids (SEC). Here, rats were fed a diet supplemented with the equivalent of 5 mg phenol/kg/day for 21 days and the HT metabolites in the gastrointestinal digesta (stomach, small intestine and caecum), plasma, urine and metabolic tissues (liver and kidney) were analysed. Compared to HT and SEC, OLE showed greater stability during digestion, and, consequently, the bioavailability based on the urine excretion of HT metabolites was higher. OLE, as a glycoside molecule, reached the colon unaltered generating more diverse microbial metabolites. In terms of bioavailability, findings suggest that OLE might be the most suitable precursor of HT for incorporation into foods or nutraceutical formulations.
  • Otros:

    Autor según el artículo: López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M. Carme Piñol; Alba Macià; María-Paz Romero; Rosa Solà; Laura Rubió; Maria-José Motilva
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: PEDRET FIGUEROLA, ANNA, SOLÀ ALBERICH, ROSA MARIA
    Palabras clave: Hydroxytyrosol Microbial catabolism Metabolic pathways
    Resumen: This study investigated and compared the absorption, metabolism, and subsequently, the tissue distribution and excretion of hydroxytyrosol (HT) administered either in its free form or through its naturally occurring esterified precursors, namely oleuropein (OLE) and its aglycone forms known as secoiridoids (SEC). Here, rats were fed a diet supplemented with the equivalent of 5 mg phenol/kg/day for 21 days and the HT metabolites in the gastrointestinal digesta (stomach, small intestine and caecum), plasma, urine and metabolic tissues (liver and kidney) were analysed. Compared to HT and SEC, OLE showed greater stability during digestion, and, consequently, the bioavailability based on the urine excretion of HT metabolites was higher. OLE, as a glycoside molecule, reached the colon unaltered generating more diverse microbial metabolites. In terms of bioavailability, findings suggest that OLE might be the most suitable precursor of HT for incorporation into foods or nutraceutical formulations.
    Grupo de investigación: Unitat de Recerca de Lípids i Arteriosclerosi
    Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1756-4646
    Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Fecha de alta del registro: 2016-04-19
    Página final: 63
    Volumen de revista: 22
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S1756464616000335
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1016/j.jff.2016.01.030
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Página inicial: 52
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Hydroxytyrosol
    Metabolisme microbià
    Vies metabòliques
    Hydroxytyrosol
    Microbial catabolism
    Metabolic pathways
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    1756-4646
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