Autor según el artículo: López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M. Carme Piñol; Alba Macià; María-Paz Romero; Rosa Solà; Laura Rubió; Maria-José Motilva
Departamento: Medicina i Cirurgia
Autor/es de la URV: PEDRET FIGUEROLA, ANNA, SOLÀ ALBERICH, ROSA MARIA
Palabras clave: Hydroxytyrosol Microbial catabolism Metabolic pathways
Resumen: This study investigated and compared the absorption, metabolism, and subsequently, the tissue distribution and excretion of hydroxytyrosol (HT) administered either in its free form or through its naturally occurring esterified precursors, namely oleuropein (OLE) and its aglycone forms known as secoiridoids (SEC). Here, rats were fed a diet supplemented with the equivalent of 5 mg phenol/kg/day for 21 days and the HT metabolites in the gastrointestinal digesta (stomach, small intestine and caecum), plasma, urine and metabolic tissues (liver and kidney) were analysed. Compared to HT and SEC, OLE showed greater stability during digestion, and, consequently, the bioavailability based on the urine excretion of HT metabolites was higher. OLE, as a glycoside molecule, reached the colon unaltered generating more diverse microbial metabolites. In terms of bioavailability, findings suggest that OLE might be the most suitable precursor of HT for incorporation into foods or nutraceutical formulations.
Grupo de investigación: Unitat de Recerca de Lípids i Arteriosclerosi
Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1756-4646
Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Fecha de alta del registro: 2016-04-19
Página final: 63
Volumen de revista: 22
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S1756464616000335
DOI del artículo: 10.1016/j.jff.2016.01.030
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Página inicial: 52
Tipo de publicación: Article Artículo Article
Repositori URV