Autor según el artículo: Marta Romeu; Laura Rubió; Vanessa Sánchez-Martos; Olga Castaner; Rafael de la Torre; Rosa M. Valls; Rosa Ras; Anna Pedret; Úrsula Catalán; María del Carmen López de las Hazas; María J. Motilva; Montserrat Fito; Rosa Solà; Montserrat Giralt
Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: ROMEU FERRAN, MARTA; Laura Rubio; SÁNCHEZ MARTOS, VANESSA; Olga Castan¿er; Rafael de la Torre; VALLS ZAMORA, ROSA MARIA; Rosa Ras; PEDRET FIGUEROLA, ANNA; CATALÁN SANTOS, ÚRSULA; María del Carmen Lo¿pez de las Hazas; María J. Motilva; Montserrat Fito; SOLÀ ALBERICH, ROSA MARIA; GIRALT BATISTA, MONTSERRAT
Palabras clave: phenol enrichment thyme phenols virgin olive oil
Resumen: The effects of virgin olive oil (VOO) enriched with its own phenolic compounds (PC) and/or thyme PC on the protection against oxidative DNA damage and antioxidant endogenous enzymatic system (AEES) were estimated in 33 hyperlipidemic subjects after the consumption of VOO, VOO enriched with its own PC (FVOO), or VOO complemented with thyme PC (FVOOT). Compared to pre-intervention, 8-hydroxy-2′-deoxyguanosine (a marker for DNA damage) decreased in the FVOO intervention and to a greater extent in the FVOOT with a parallel significant increase in olive and thyme phenolic metabolites. Superoxide dismutase (AEES enzyme) significantly increased in the FVOO intervention and to a greater extent in the FVOOT with a parallel significant increase in thyme phenolic metabolites. When all three oils were compared, FVOOT appeared to have the greatest effect in protecting against oxidative DNA damage and improving AEES. The sustained intake of a FVOOT improves DNA protection against oxidation and AEES probably due to a greater bioavailability of thyme PC in hyperlipidemic subjects.
Grupo de investigación: Farmacobiologia Cel.lular Unitat de Recerca de Lípids i Arteriosclerosi
Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0021-8561
Identificador del autor: orcid.org/0000-0002-2131-1858; N/D; N/D; N/D; N/D; N/D; N/D; orcid.org/0000-0002-5327-932X; N/D; orcid.org/0000-0001-8199-6724; N/D; orcid.org/0000-0002-1817-483X; orcid.org/0000-0002-8359-235X; orcid.org/0000-0002-7073-577X
Fecha de alta del registro: 2016-05-12
Página final: 1888
Volumen de revista: 64
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://pubs.acs.org/doi/10.1021/acs.jafc.5b04915
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1021/acs.jafc.5b04915
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Página inicial: 1879
Tipo de publicación: Article Artículo Article
Repositori URV