Autor según el artículo: Jorge Joven; Anabel García-Heredia; Marta Riera-Borrull; Isabel Fort-Gallifa; Fedra Luciano-Mateo; Noemí Cabré; Anna Hernandez-Aguilera; Jordi Camps
Departamento: Medicina i Cirurgia
Autor/es de la URV: JOVEN MARIED, JORGE; Anabel García-Heredia; Marta Riera-Borrull; Isabel Fort-Gallifa; Fedra Luciano-Mateo; Noemí Cabré; Anna Hernandez-Aguilera; CAMPS ANDREU, JORGE
Palabras clave: metformin Paraoxonase Antioxidants
Resumen: Metformin is the first-line pharmacological treatment of diabetes. In these patients, metformin reduces body weight and decreases the risk of diabetes-related complications such as cardiovascular disease. However, whether metformin elicits beneficial effects on liver histology is a controversial issue and, as yet, there is no consensus. Paraoxonase-1 (PON1), an enzyme synthesized mainly by the liver, degrades lipid peroxides and reduces oxidative stress. PON1 activities are decreased in chronic liver diseases. We evaluated the effects of metformin in the liver of PON1-deficient mice which, untreated, present a mild degree of liver steatosis. Metformin administration aggravated inflammation in animals given a standard mouse chow and in those fed a high-fat diet. Also, it was associated with a higher degree of steatosis in animals fed a standard chow diet. This report is a cautionary note regarding the prescription of metformin for the treatment of diabetes in patients with concomitant liver impairment.
Grupo de investigación: Unitat de Recerca Biomèdica
Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0009-2797
Identificador del autor: orcid.org/0000-0003-2749-4541; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Fecha de alta del registro: 2016-05-24
Página final: 63
Volumen de revista: 249
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0009279716300679
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.cbi.2016.03.004
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Página inicial: 56
Tipo de publicación: Article Artículo Article