Autor según el artículo: Jordi Salas-Salvadó; Xiaohui Guo; Anna Tresserra-Rimbau; Ramón Estruch; Miguel A. Martínez-González; Alexander Medina-Remón; Olga Castañer; Dolores Corella; Rosa M. Lamuela-Raventós
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: SALAS SALVADÓ, JORGE; Xiaohui Guo; Anna Tresserra-Rimbau; Ramón Estruch; Miguel A. Martínez-González; Alexander Medina-Remón; Olga Castañer; Dolores Corella; Rosa M. Lamuela-Raventós
Palabras clave: Cholesterol Blood pressure Biomarkers
Resumen: Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) from the PREDIMED study (ISRCTN35739639). We used Folin-Ciocalteu method to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration (β = - 8.563; P = 0.007), glucose concentration (β = - 4.164; P = 0.036), and diastolic blood pressure (β = - 1.316; P = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.
Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental
Áreas temáticas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1942-0900
Identificador del autor: 0000-0003-2700-7459; n/a; 0000-0002-7022-9041; 0000-0003-1260-4445; n/a; 0000-0003-1985-7592; n/a; 0000-0002-2366-4104; 0000-0002-1287-4560
Fecha de alta del registro: 2016-06-10
Volumen de revista: 2016
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Página inicial: Article number 2572606
Tipo de publicación: Article Artículo Article
Repositori URV