Articles producció científica> Bioquímica i Biotecnologia

Plasma acyl-estrone levels are altered in obese women

  • Datos identificativos

    Identificador: PC:1637
    Autores:
    M Bullo BonetC CabotR MasanesP Garcia-LordaJA Fernandez LopezJ Salas SalvadoM Alemany
    Resumen:
    A group of obese women (BMI>27 kg/m2; N=73) was studied together with lean controls (BMI <27 kg/m2; N=25). Three groups were defined by the compliance with: BMI lower than 27 kg/m2, glycaemia lower than 5.5 mM and insulinaemia lower than 0.2 nM (controls, group 1, N=19). The subjects with BMI>27 kg/m2, glucose >5.5 mM and insulin >0.2 nM constituted group 3 (N=41), and those with BMI>27 with glycaemia and/or insulinaemia lower than the limits set constituted group 2 (N=32). The women in group 3 had higher fat content, BMI and fat-free mass than those in group 2 and the controls. There were no changes in most plasma parameters, such as free estrone and beta-estradiol. Leptin levels were higher in groups 2 and 3 than in controls. In controls, leptin and acyl-estrone levels were well correlated with BMI and fat content; this correlation was not found in groups 2 and 3 for acyl-estrone, although it was found for leptin. Acyl-estrone levels were lower than expected in most obese women when compared to those of controls, suggesting an altered availability or function of this hormone. In obese women, acyl-estrone levels -and probably function- are lower than expected, contrasting with maintained leptin-BMI correlations. The role of insulin in the control of body weight, perhaps through acyl estrone-mediated effects, should be re-evaluated.
  • Otros:

    Autor según el artículo: M Bullo Bonet; C Cabot; R Masanes; P Garcia-Lorda; JA Fernandez Lopez; J Salas Salvado; M Alemany
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: BULLÓ BONET, MÒNICA; C Cabot; R Masanes; P Garcia-Lorda; JA Fernandez Lopez; SALAS SALVADÓ, JORGE; M Alemany
    Palabras clave: Plasma obese women
    Resumen: A group of obese women (BMI>27 kg/m2; N=73) was studied together with lean controls (BMI <27 kg/m2; N=25). Three groups were defined by the compliance with: BMI lower than 27 kg/m2, glycaemia lower than 5.5 mM and insulinaemia lower than 0.2 nM (controls, group 1, N=19). The subjects with BMI>27 kg/m2, glucose >5.5 mM and insulin >0.2 nM constituted group 3 (N=41), and those with BMI>27 with glycaemia and/or insulinaemia lower than the limits set constituted group 2 (N=32). The women in group 3 had higher fat content, BMI and fat-free mass than those in group 2 and the controls. There were no changes in most plasma parameters, such as free estrone and beta-estradiol. Leptin levels were higher in groups 2 and 3 than in controls. In controls, leptin and acyl-estrone levels were well correlated with BMI and fat content; this correlation was not found in groups 2 and 3 for acyl-estrone, although it was found for leptin. Acyl-estrone levels were lower than expected in most obese women when compared to those of controls, suggesting an altered availability or function of this hormone. In obese women, acyl-estrone levels -and probably function- are lower than expected, contrasting with maintained leptin-BMI correlations. The role of insulin in the control of body weight, perhaps through acyl estrone-mediated effects, should be re-evaluated.
    Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental
    Áreas temáticas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0743-5800
    Identificador del autor: orcid.org/0000-0002-0218-7046; N/D; N/D; orcid.org/0000-0001-8938-7229; N/D; orcid.org/0000-0003-2700-7459; N/D
    Fecha de alta del registro: 2016-06-08
    Página final: 476
    Volumen de revista: 26
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2000
    Página inicial: 465
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Obesitat
    Dones
    Plasma sanguini
    Plasma
    obese women
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    0743-5800
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