Autor según el artículo: Monica Bullo Bonet; Pilar Garcia Lorda; Pilar Serrano; Maria Jesus Jimenez-Expósito; Julia Fraile; Carlos Alonso; Anna Bonada; Pompeyo Viciana; Pedro P Garcia Luna ; Jordi Salas Salvado

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: BULLÓ BONET, MÒNICA; Pilar Garcia Lorda; Pilar Serrano; Maria Jesus Jimenez-Expósito; Julia Fraile; Carlos Alonso; Anna Bonada; Pompeyo Viciana; Pedro P Garcia Luna ; SALAS SALVADÓ, JORGE

Palabras clave: hypermetabolism aids

Resumen: BACKGROUND: To assess a possible role of systemic inflammation in the resting metabolic response in AIDS patients with active secondary infections. METHODS: Fifty-two patients with AIDS-defined criteria and concomitant active infections and 19 healthy subjects were studied. Measurements were as follows: body composition assessed by bioelectrical impedance; resting energy expenditure (REE) by 30-minute indirect calorimetry; cytokine concentrations (IL-6, IFNalpha, TNFalpha, sTNF-R1) by ELISA; C-reactive protein (CRP), erythrocyte sedimentation rate, fibrinogen, and nutritional parameters by standard techniques. RESULTS: REE adjusted for fat-free mass (REEFFM) was significantly increased in AIDS patients despite 39% of them not being hypermetabolic. The patients were undernourished and were found to have increased levels of acute-phase proteins and increased concentrations of IL-6 and sTNF-R1 relative to controls. REE parameters were positively related to CRP, ESR, ferritin, IL-6, and sTNF-R1 and negatively related to albumin, prealbumin, and transferrin. CRP was an independent predictor of REEFFM in AIDS patients and explained 25% of its variability. Patients with severe inflammation (CRP > or = 37 mg/dL) were significantly hypermetabolic with respect to patients without inflammation (CRP < 6 mg/dL) and had higher levels of IL-6 and sTNF-R1 and lower levels of albumin and prealbumin. Although no significant differences were observed with respect to the infection type, patients with tuberculosis and Pneumocystis carinii infections had higher resting metabolic and inflammatory responses, whereas patients with recurrent bacterial pneumonia were normometabolic and had lower levels of inflammatory markers. CONCLUSIONS: Resting hypermetabolism observed in AIDS patients with concurrent active infections is related to the presence and severity of systemic cytokine-driven inflammatory response, which could reflect the type of secondary infection.

Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental

Áreas temáticas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0148-6071

Identificador del autor: orcid.org/0000-0002-0218-7046; orcid.org/0000-0001-8938-7229; N/D; N/D; N/D; N/D; N/D; N/D; N/D; orcid.org/0000-0003-2700-7459

Fecha de alta del registro: 2016-06-08

Página final: 320

Volumen de revista: 24

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2000

Página inicial: 317

Tipo de publicación: Article Artículo Article