Articles producció científica> Bioquímica i Biotecnologia

Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population.

  • Datos identificativos

    Identificador: PC:1728
    Autores:
    Jordi Salas-SalvadóDolores CorellaPaula CarrascoMontserrat FitóMiguel Angel Martínez-GonzálezFernando ArósJosé LapetraMarisa GuillénCarolina Ortega-AzorínJulia WarnbergMiquel FiolValentina Ruiz-GutierrezLluís Serra-MajemJ. Alfredo MartínezEmilio RosRamón Estruch
    Resumen:
    Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D'= 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.
  • Otros:

    Autor según el artículo: Jordi Salas-Salvadó; Dolores Corella; Paula Carrasco; Montserrat Fitó; Miguel Angel Martínez-González; Fernando Arós; José Lapetra; Marisa Guillén; Carolina Ortega-Azorín; Julia Warnberg; Miquel Fiol; Valentina Ruiz-Gutierrez; Lluís Serra-Majem; J. Alfredo Martínez; Emilio Ros; Ramón Estruch
    Departamento: Bioquímica i Biotecnologia
    e-ISSN: 1539-7262
    Autor/es de la URV: Salas Salvadó, Jordi
    Palabras clave: lipids nutrigenetics Alcohol
    Resumen: Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D'= 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.
    Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental
    Áreas temáticas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0022-2275
    Fecha de alta del registro: 2016-06-13
    Página final: 2807
    Volumen de revista: 51
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.jlr.org/content/early/2010/06/25/jlr.P005199
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1194/jlr.P005199
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2010
    Página inicial: 2798
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Nutrició -- Aspectes genètics
    Sistema cardiovascular -- Malalties -- Factors de risc
    Mediterrània, Regió -- Població
    lipids
    nutrigenetics
    Alcohol
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    0022-2275
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