Autor según el artículo: Pedro Romero-Aroca; Marc Baget-Bernaldiz; Alicia Pareja-Rios; Maribel Lopez-Galvez; Raul Navarro-Gil; Raquel Verges
Departamento: Medicina i Cirurgia
Autor/es de la URV: ROMERO AROCA, PEDRO; Marc Baget-Bernaldiz; Alicia Pareja-Rios; Maribel Lopez-Galvez; Raul Navarro-Gil; Raquel Verges
Palabras clave: Pathophysiology Diabetic macular edema
Resumen: Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease. However, it still remains to be clarified whether angiogenesis following VEGF overexpression is a cause or a consequence of inflammation. This paper provides a review of the data currently available, focusing on VEGF, angiogenesis, and inflammation. Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME. Knowledge of DME etiology seems to be important in treatments with anti-VEGF or anti-inflammatory drugs. Current diagnostic techniques do not permit us to differentiate between both etiologies. In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug.
Grupo de investigación: Grup de Recerca d'Oftalmologia
Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2314-6745
Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D
Fecha de alta del registro: 2016-11-02
Volumen de revista: 2016
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Página inicial: Art.num. 2156273
Tipo de publicación: Article Artículo Article
Repositori URV