Autor según el artículo: Oscar Pàmies; Jèssica Margalef; Montserrat Diéguez

Departamento: Química Física i Inorgànica

Autor/es de la URV: PAMIES OLLÉ, OSCAR; Jèssica Margalef; DIÉGUEZ FERNÁNDEZ, MONTSERRAT

Palabras clave: asymmetric transfer hydrogenation ketones sugar-based ligands

Resumen: Asymmetric transfer hydrogenation (ATH) has emerged as one of the most effective and sustainable synthetic tool for synthesizing enantiopure alcohols. Since Noyori’s group successfully applied Ru-catalysts modified with chiral b-amino alcohols or diamines as ligands, a large number of catalytic systems has been successfully developed. However, further improvement in terms of substrate scope, selectivity, and turnover frequency are required to make the process competitive with conventional hydrogenations. Overcoming these limitations requires research toward the design of new ligands. Such a task becomes easier if readily modulable chiral ligands are at hand. Sugar-based ligands are particularly useful for addressing this need. They are readily available, highly functionalized, and their modular constructions are easy. Series of chiral ligands can be screened in the search for high activities and selectivities for each type of substrate. This digest paper will discuss the progress on the use of sugar-based ligands in ATH reactions.

Grupo de investigación: Organometàl.lics i Catàlisi Homogènia

Áreas temáticas: Química Química Chemistry

Acceso a la licencia de uso: thttps://creativecommons.org/licenses/by/3.0/es/

ISSN: 0040-4039

Identificador del autor: 0000-0002-2352-8508; n/a; 0000-0002-8450-0656

Fecha de alta del registro: 2017-02-22

Página final: 1308

Volumen de revista: 57

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0040403916301320

DOI del artículo: https://doi.org/10.1016/j.tetlet.2016.02.022

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Página inicial: 1301

Tipo de publicación: Post-print