Autor según el artículo: Camps, J.; Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; Joven, J.
Departamento: Medicina i Cirurgia
Autor/es de la URV: CAMPS ANDREU, JORGE; Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; JOVEN MARIED, JORGE
Palabras clave: obesity Energy intake Diabetes mellitus
Resumen: Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations.
Grupo de investigación: Unitat de Recerca Biomèdica
Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2072-6643
Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Fecha de alta del registro: 2017-03-06
Volumen de revista: 9
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Página inicial: Art.num. 121
Tipo de publicación: Article Artículo Article
Repositori URV