Autor según el artículo: Salas-Salvadó, J.; Amor, A.; Serra-Mir, M.; Martínez-González, M.A.; Corella, D.; Fitó, M.; Estruch, R.; Serra-Majem, L.; Arós, F.; Babio, N.; Ros, E.; Ortega, E.

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: SALAS SALVADÓ, JORGE; Amor, A.; Serra-Mir, M.; Martínez-González, M.A.; Corella, D.; Fitó, M.; Estruch, R.; Serra-Majem, L.; Arós, F.; BABIO SÁNCHEZ, NANCY ELVIRA; Ros, E.; Ortega, E.

Palabras clave: cardiovascular disease Framingham-REGICOR equation Cardiovascular risk prediction

Resumen: Background-The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories. Methods and Results-In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED participants (aged 55-74 years, 57% women; 48% with type 2 diabetes mellitus). Major CVD events, the primary PREDIMED end point, were an aggregate of myocardial infarction, stroke, and cardiovascular death. Multivariate-adjusted Cox regression was used to calculate hazard ratios for major CVD events and effect modification from the Mediterranean diet intervention across risk strata (low, moderate, high, very high). The Framingham-REGICOR classification of PREDIMED participants was 25.1% low risk, 44.5% moderate risk, and 30.4% high or very high risk. During 6-year follow-up, 188 major CVD events occurred. Hazard ratios for major CVD events increased in parallel with estimated risk (2.68, 4.24, and 6.60 for moderate, high, and very high risk), particularly in men (7.60, 13.16, and 15.85, respectively, versus 2.16, 2.28, and 3.51, respectively, in women). Yet among those with low or moderate risk, 32.2% and 74.3% of major CVD events occurred in men and women, respectively. Mediterranean diet adherence was associated with CVD risk reduction regardless of risk strata (P > 0.4 for interaction). Conclusions-Incident CVD increased in parallel with estimated risk in the PREDIMED cohort, but most events occurred in non- high-risk categories, particularly in women. Until predictive tools are improved, promotion of the Mediterranean diet might be useful to reduce CVD independent of baseline risk.

Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental

Áreas temáticas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 2047-9980

Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D

Fecha de alta del registro: 2017-03-28

Volumen de revista: 6

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.ahajournals.org/doi/10.1161/JAHA.116.004803

DOI del artículo: 10.1161/JAHA.116.004803

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Página inicial: Art.num. e004803

Tipo de publicación: Article Artículo Article