Articles producció científica> Ciències Mèdiques Bàsiques

Daylight photodynamic therapy using methylene blue to treat sheep with dermatophytosis caused by Arthroderma vanbreuseghemii

  • Datos identificativos

    Identificador: PC:2626
  • Autores:

    Perez-Laguna, Vanesa
    Rezusta, Antonio
    Jose Ramos, Juan
    Miguel Ferrer, Luis
    Gene, Josepa
    Jose Revillo, Maria
    Gilaberte, Yolanda
  • Otros:

    Autor según el artículo: Perez-Laguna, Vanesa; Rezusta, Antonio; Jose Ramos, Juan; Miguel Ferrer, Luis; Gene, Josepa; Jose Revillo, Maria; Gilaberte, Yolanda;
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: GENÉ DÍAZ, JOSEPA; Pérez-Laguna, V.; Rezusta, A.; Ramos, J.J.; Ferrer, L.M.; Revillo, M.J.; Gilaberte, Y.
    Palabras clave: Photodynamic therapy
    Resumen: Arthroderma vanbreuseghemii has been identified molecularly as the causative agent of dermatophytosis in a flock of sheep. It is necessary to explore new treatment alternatives because antifungals are not approved for use on small ruminant animals in the European Union. Antimicrobial photodynamic therapy (aPDT) has been shown to be effective for the treatment of dermatophytosis in humans. It is based on the application of a photosensitizer such as methylene blue (MB) that is activated by visible light to generate reactive oxygen species that are cytotoxic to cells. The use of daylight to perform aPDT (aDL-PDT) avoids the requirement of specific equipment because it uses sunlight to activate the photosensitizer. The aim of our study is to determine the efficacy of aDL-PDT using a 1% MB solution to treat dermatophytosis caused by A. vanbreuseghemii in ewes. Two different topical protocols (1% MB solution spray applications once or twice a week) were assayed in two groups of five infected animals. Twenty-five infected sheep were untreated. All the sheep were exposed to sunlight every day for an approximate duration of 10 h for a total of four weeks. At the end of the study, all the animals treated with aDL-PDT showed the same clinical response to both protocols. In contrast, the animals exposed only to sunlight required an additional two to four weeks before their infections resolved. Conclusion: aDL-PDT with 1% MB solution demonstrates efficacy, safety and efficiency in the treatment of dermatophytosis in sheep.
    Grupo de investigación: Unitat de Micologia i Microbiologia Ambiental
    Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0921-4488
    Fecha de alta del registro: 2017-04-19
    Página final: 101
    Volumen de revista: 150
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0921448817300792?via%3Dihub
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1016/j.smallrumres.2017.03.011
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Página inicial: 97
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Dermatòfits
    Fototeràpia
    Photodynamic therapy
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    0921-4488
  • Documentos:

  • Cerca a google

    Search to google scholar