Autor según el artículo: Hernández-Alonso P, Cañueto D, Giardina S, Salas-Salvadó J, Cañellas N, Correig X, Bulló M.

Departamento: Enginyeria Electrònica Bioquímica i Biotecnologia

Autor/es de la URV: Hernández-Alonso, P.; Cañueto, D.; Giardina, S.; SALAS SALVADÓ, JORGE; CAÑELLAS ALBERICH, NICOLAU; CORREIG BLANCHAR, FRANCESC XAVIER; BULLÓ BONET, MÒNICA

Palabras clave: Microbiota metabolomics Insulin resistance

Resumen: The specific nutritional composition of nuts could affect different metabolic pathways involved in a broad range of metabolic diseases. We therefore investigated whether chronic consumption of pistachio nuts modifies the urine metabolome in prediabetic subjects. We designed a randomized crossover clinical trial in 39 prediabetic subjects. They consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57 g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Nuclear magnetic resonance (NRM) was performed to determine changes in 24-h urine metabolites. Significant changes in urine metabolites according to the different intervention periods were found in uni- and multivariate analysis. Score plot of the first two components of the multilevel partial least squares discriminant analysis (ML-PLS-DA) showed a clear separation of the intervention periods. Three metabolites related with gut microbiota metabolism (i.e., hippurate, p-cresol sulfate and dimethylamine) were found decreased in PD compared with CD (P<.05). Moreover, cis-aconitate [intermediate of the tricarboxylic acid (TCA)] was also found decreased following PD compared with CD. Intragroup analysis showed that creatinine levels were significantly increased in PD (P=.023), whereas trimethylamine N-oxide (TMAO) was found significantly reduced following PD (P=.034). Our results suggest that chronic pistachio consumption may modulate some urinary metabolites related to gut microbiota metabolism and the TCA cycle; all associated with metabolic derangements associated with insulin resistance and Type 2 diabetes.

Grupo de investigación: Signal Processing for Omic Sciences Alimentació, Nutrició, Creixement i Salut Mental

Áreas temáticas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0955-2863

Identificador del autor: orcid.org/0000-0003-2700-7459; N/D; N/D; N/D; orcid.org/0000-0003-4856-8132; orcid.org/0000-0002-6902-3054; orcid.org/0000-0002-0218-7046

Fecha de alta del registro: 2017-05-03

Página final: 53

Volumen de revista: 45

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0955286316306490?via%3Dihub

DOI del artículo: 10.1016/j.jnutbio.2017.04.002

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Página inicial: 48

Tipo de publicación: Article Artículo Article