Autor según el artículo: Mas, A.; González, B.; Beltran, G.; Cullen, P.J.; Torija, M.J.

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: MAS BARON, ALBERTO; González, B.; BELTRAN CASELLAS, GEMMA; Cullen, P.J.; TORIJA MARTÍNEZ, MARÍA JESÚS

Palabras clave: filamentous growth pseudohyphal growth quorum sensing

Resumen: In yeast, ethanol is produced as a by-product of fermentation through glycolysis. Ethanol also stimulates a developmental foraging response called filamentous growth and is thought to act as a quorum-sensing molecule. Ethanol-inducible filamentous growth was examined in a small collection of wine/European strains, which validated ethanol as an inducer of filamentous growth. Wine strains also showed variability in their filamentation responses, which illustrates the striking phenotypic differences that can occur among individuals. Ethanol-inducible filamentous growth in 61278b strains was independent of several of the major filamentation regulatory pathways [including fMAPK, RAS-cAMP, Snf1, Rpd3(L), and Rim101] but required the mitochondrial retrograde (RTG) pathway, an inter-organellar signaling pathway that controls the nuclear response to defects in mitochondrial function. The RTG pathway regulated ethanol-dependent filamentous growth by maintaining flux through the TCA cycle. The ethanol-dependent invasive growth response required the polarisome and transcriptional induction of the cell adhesion molecule Flo11p. Our results validate established stimuli that trigger filamentous growth and show how stimuli can trigger highly specific responses among individuals. Our results also connect an inter-organellar pathway to a quorum sensing response in fungi.

Grupo de investigación: Biotecnologia Enològica

Áreas temáticas: Enologia Enología Oenology

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1664-042X

Identificador del autor: 0000-0002-0763-1679; n/a; 0000-0002-7071-205X; n/a; 0000-0001-6419-0745

Fecha de alta del registro: 2017-05-18

Volumen de revista: 8

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: http://journal.frontiersin.org/article/10.3389/fphys.2017.00148/full

DOI del artículo: 10.3389/fphys.2017.00148

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Página inicial: Art.num. 148

Tipo de publicación: Article Artículo Article