Autor según el artículo: Simó, J.M.; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; Paredero, V.M.; Camps, J.; Joven, J.

Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia

Autor/es de la URV: SIMÓ SISÓ, JOSÉ MARIA; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; MARTÍN PAREDERO, VICENTE; CAMPS ANDREU, JORGE; JOVEN MARIED, JORGE

Palabras clave: Galectin-3 F2-isoprostanes atherosclerosis

Resumen: Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries. Plasma from 86 patients was compared with that from 72 control subjects. We observed differences in the expression of galectin-3 in normal arteries, and arteries from patients with PAD, with a displacement of the expression from the adventitia to the media, and the intima. In addition, plasma galectin-3 concentration was increased in PAD patients, and correlated with serologic markers of oxidative stress (F2-isoprostanes), and inflammation [chemokine (C–C motif) ligand 2, C-reactive protein, β-2-microglobulin]. We conclude that the determination of galectin-3 has good diagnostic accuracy in the assessment of PAD and compares well with other analytical parameters currently in use.

Grupo de investigación: Unitat de Recerca Biomèdica

Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1661-6596

Identificador del autor: ; ; ; ; ; ; 0000-0002-2740-5847; ; 0000-0003-2749-4541

Fecha de alta del registro: 2017-05-26

Volumen de revista: 18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: http://www.mdpi.com/1422-0067/18/5/973

Programa de financiación: european; FEDER; PI15/00285 european; FEDER; PI11/00130 european; FEDER; PI11/02817

DOI del artículo: 10.3390/ijms18050973

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Página inicial: 973

Tipo de publicación: Article Artículo Article