Autor según el artículo: Simó, J.M.; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; Paredero, V.M.; Camps, J.; Joven, J.
Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia
Autor/es de la URV: SIMÓ SISÓ, JOSÉ MARIA; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; MARTÍN PAREDERO, VICENTE; CAMPS ANDREU, JORGE; JOVEN MARIED, JORGE
Palabras clave: Galectin-3 F2-isoprostanes atherosclerosis
Resumen: Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries. Plasma from 86 patients was compared with that from 72 control subjects. We observed differences in the expression of galectin-3 in normal arteries, and arteries from patients with PAD, with a displacement of the expression from the adventitia to the media, and the intima. In addition, plasma galectin-3 concentration was increased in PAD patients, and correlated with serologic markers of oxidative stress (F2-isoprostanes), and inflammation [chemokine (C–C motif) ligand 2, C-reactive protein, β-2-microglobulin]. We conclude that the determination of galectin-3 has good diagnostic accuracy in the assessment of PAD and compares well with other analytical parameters currently in use.
Grupo de investigación: Unitat de Recerca Biomèdica
Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1661-6596
Identificador del autor: ; ; ; ; ; ; 0000-0002-2740-5847; ; 0000-0003-2749-4541
Fecha de alta del registro: 2017-05-26
Volumen de revista: 18
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: http://www.mdpi.com/1422-0067/18/5/973
Programa de financiación: european; FEDER; PI15/00285 european; FEDER; PI11/00130 european; FEDER; PI11/02817
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.3390/ijms18050973
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Página inicial: 973
Tipo de publicación: Article Artículo Article