Articles producció científica> Medicina i Cirurgia

Galectin-3 in peripheral artery disease. Relationships with markers of oxidative stress and inflammation

  • Datos identificativos

    Identificador: PC:2829
    Autores:
    Simó, J.M.Gallifa, I.F.Aguilera, A.H.Heredia, A.G.Cabré, N.Mateo, F.L.Paredero, V.M.Camps, J.Joven, J.
    Resumen:
    Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries. Plasma from 86 patients was compared with that from 72 control subjects. We observed differences in the expression of galectin-3 in normal arteries, and arteries from patients with PAD, with a displacement of the expression from the adventitia to the media, and the intima. In addition, plasma galectin-3 concentration was increased in PAD patients, and correlated with serologic markers of oxidative stress (F2-isoprostanes), and inflammation [chemokine (C–C motif) ligand 2, C-reactive protein, β-2-microglobulin]. We conclude that the determination of galectin-3 has good diagnostic accuracy in the assessment of PAD and compares well with other analytical parameters currently in use.
  • Otros:

    Autor según el artículo: Simó, J.M.; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; Paredero, V.M.; Camps, J.; Joven, J.
    Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    Autor/es de la URV: SIMÓ SISÓ, JOSÉ MARIA; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; MARTÍN PAREDERO, VICENTE; CAMPS ANDREU, JORGE; JOVEN MARIED, JORGE
    Palabras clave: Galectin-3 F2-isoprostanes atherosclerosis
    Resumen: Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries. Plasma from 86 patients was compared with that from 72 control subjects. We observed differences in the expression of galectin-3 in normal arteries, and arteries from patients with PAD, with a displacement of the expression from the adventitia to the media, and the intima. In addition, plasma galectin-3 concentration was increased in PAD patients, and correlated with serologic markers of oxidative stress (F2-isoprostanes), and inflammation [chemokine (C–C motif) ligand 2, C-reactive protein, β-2-microglobulin]. We conclude that the determination of galectin-3 has good diagnostic accuracy in the assessment of PAD and compares well with other analytical parameters currently in use.
    Grupo de investigación: Unitat de Recerca Biomèdica
    Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1661-6596
    Identificador del autor: ; ; ; ; ; ; 0000-0002-2740-5847; ; 0000-0003-2749-4541
    Fecha de alta del registro: 2017-05-26
    Volumen de revista: 18
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: http://www.mdpi.com/1422-0067/18/5/973
    Programa de financiación: european; FEDER; PI15/00285 european; FEDER; PI11/00130 european; FEDER; PI11/02817
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3390/ijms18050973
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Página inicial: 973
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Estrès oxidatiu -- Aspectes moleculars
    Lectines
    Aterosclerosi
    Galectin-3
    F2-isoprostanes
    atherosclerosis
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    1661-6596
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