Autor según el artículo: Tebé, C.; Contreras, F.; Albacete, A.; Benejam, B.; Caño, A.; Menchón, J.M.

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: TEBÉ CORDOMÍ, CRISTIAN; Contreras, F.; Albacete, A.; Benejam, B.; Caño, A.; Menchón, J.M.

Palabras clave: schizophrenia Pathophysiology Neuropsychological test

Resumen: Previous research has associated schizophrenia with an inability to activate behavioural intentions facilitated by counterfactual thinking (CFT) as a step to improving performance. Consequently, these findings suggest that rehabilitation strategies will be entirely ineffective. To extend previous research, we evaluated the influence of CFT in the activation of behavioural intentions using a novel sequential priming paradigm in the largest sample of subjects explored to date. Method: The main variables assessed were: answer to complete a target task (wrong or correctly), and percentage gain in the reaction time (RT) to complete a target task correctly depending on whether the prime was a counterfactual or a neutral-control cue. These variables were assessed in 37 patients with schizophrenia and 37 healthy controls. Potential associations with clinical status and socio-demographic characteristics were also explored. Results: When a counterfactual prime was presented, the probability of giving an incorrect answer was lower for the entire sample than when a neutral prime was presented (OR 0.58; CI 95% 0.42 to 0.79), but the schizophrenia patients showed a higher probability than the controls of giving an incorrect answer (OR 3.89; CI 95% 2.0 to 7.6). Both the schizophrenia patients and the controls showed a similar percentage gain in RT to a correct answer of 8%. Conclusions: Challenging the results of previous research, our findings suggest a normal activation of behavioural intentions facilitated by CFT in schizophrenia. Nevertheless, the patients showed more difficulty than the controls with the task, adding support to the concept of CFT as a potential new target for consideration in future therapeutic approaches for this illness.

Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1932-6203

Identificador del autor: 0000-0003-2320-1385; ; ; ; ;

Fecha de alta del registro: 2017-10-17

Volumen de revista: 12

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178860

Programa de financiación: altres; Universitat de Barcelona; UB; altres; Ministerio de Ciencia e Innovación; MICINN; PI08/1118 altres; Instituto de Salud Carlos III; ISCIII; PI08/1118

DOI del artículo: 10.1371/journal.pone.0178860

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Página inicial: e0178860

Tipo de publicación: Article Artículo Article