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Combining cationic and anionic mixed-mode sorbents in a single cartridge to extract basic and acidic pharmaceuticals simultaneously from environmental samples

  • Datos identificativos

    Identificador: PC:3024
    Handle: https://hdl.handle.net/20.500.11797/PC3024
    Autores:
    Borrull, F.Salas, D.Fontanals, N.Marcé, R. M.
    Resumen:
    The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.

  • Otros:

    Autor según el artículo: Borrull, F. ; Salas, D. ; Fontanals, N. ; Marcé, R. M.
    Departamento: Química Analítica i Química Orgànica
    Autor/es de la URV: BORRULL BALLARÍN, FRANCESC; Salas, D. ; Fontanals, N. ; MARCÉ RECASENS, ROSA MARIA
    Palabras clave: Cationic mixed-mode solid-phase extraction Anionicmixed-mode solid-phase extraction High-resolutionmass spectrometry
    Resumen: The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.
    Grupo de investigación: Grup de Cromatografia. Aplicacions Mediambientals
    Áreas temáticas: Química Química Chemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1618-2642
    Identificador del autor: 0000-0003-2718-9336; ; ; 0000-0002-5667-2899
    Fecha de alta del registro: 2018-03-01
    Página final: 469
    Volumen de revista: 410
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007/s00216-017-0736-5
    Programa de financiación: plan; Excelencia; CTQ2014-52617-P plan; PhD fellowship; BES-2012-057792
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1007/s00216-017-0736-5
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2018
    Página inicial: 459
    Tipo de publicación: Article Artículo Article

  • Palabras clave:

    Extracció (Química)
    Espectrometria de masses
    Cationic mixed-mode solid-phase extraction
    Anionicmixed-mode solid-phase extraction
    High-resolutionmass spectrometry
    Química
    Química
    Chemistry
    1618-2642

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