Autor según el artículo: Borrull, F. ; Salas, D. ; Fontanals, N. ; Marcé, R. M.

Departamento: Química Analítica i Química Orgànica

Autor/es de la URV: BORRULL BALLARÍN, FRANCESC; Salas, D. ; Fontanals, N. ; MARCÉ RECASENS, ROSA MARIA

Palabras clave: Cationic mixed-mode solid-phase extraction Anionicmixed-mode solid-phase extraction High-resolutionmass spectrometry

Resumen: The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.

Grupo de investigación: Grup de Cromatografia. Aplicacions Mediambientals

Áreas temáticas: Química Química Chemistry

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1618-2642

Identificador del autor: 0000-0003-2718-9336; ; ; 0000-0002-5667-2899

Fecha de alta del registro: 2018-03-01

Página final: 469

Volumen de revista: 410

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://link.springer.com/article/10.1007/s00216-017-0736-5

Programa de financiación: plan; Excelencia; CTQ2014-52617-P plan; PhD fellowship; BES-2012-057792

DOI del artículo: 10.1007/s00216-017-0736-5

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Página inicial: 459

Tipo de publicación: Article Artículo Article