Articles producció científica> Bioquímica i Biotecnologia

Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial.

  • Datos identificativos

    Identificador: PC:3181
    Autores:
    JORDI SALAS-SALVADOMONICA BULLONANCY BABIOMIGUEL ANGEL MARTINEZ-GONZALEZNURIA IBARROLA-JURADOJOSEP BASORARAMON ESTRUCHMARIA ISABEL COVASDOLORES CORELLAFERNANDO AROSVALENTINA RUIZ-GUTIERREZEMILIO ROSPREDIMED STUDY INVESTIGATORS
    Resumen:
    OBJECTIVE: To test the effects of two Mediterranean diet (MedDiet) interventions versus a low-fat diet on incidence of diabetes. RESEARCH DESIGN AND METHODS: This was a three-arm randomized trial in 418 nondiabetic subjects aged 55-80 years recruited in one center (PREDIMED-Reus, northeastern Spain) of the Prevención con Dieta Mediterránea [PREDIMED] study, a large nutrition intervention trial for primary cardiovascular prevention in individuals at high cardiovascular risk. Participants were randomly assigned to education on a low-fat diet (control group) or to one of two MedDiets, supplemented with either free virgin olive oil (1 liter/week) or nuts (30 g/day). Diets were ad libitum, and no advice on physical activity was given. The main outcome was diabetes incidence diagnosed by the 2009 American Diabetes Association criteria. RESULTS: After a median follow-up of 4.0 years, diabetes incidence was 10.1% (95% CI 5.1-15.1), 11.0% (5.9-16.1), and 17.9% (11.4-24.4) in the MedDiet with olive oil group, the MedDiet with nuts group, and the control group, respectively. Multivariable adjusted hazard ratios of diabetes were 0.49 (0.25-0.97) and 0.48 (0.24-0.96) in the MedDiet supplemented with olive oil and nuts groups, respectively, compared with the control group. When the two MedDiet groups were pooled and compared with the control group, diabetes incidence was reduced by 52% (27-86). In all study arms, increased adherence to the MedDiet was inversely associated with diabetes incidence. Diabetes risk reduction occurred in the absence of significant changes in body weight or physical activity. CONCLUSIONS: MedDiets without calorie restriction seem to be effective in the prevention of diabetes in subjects at high cardiovascular risk.
  • Otros:

    Autor según el artículo: JORDI SALAS-SALVADO; MONICA BULLO; NANCY BABIO; MIGUEL ANGEL MARTINEZ-GONZALEZ; NURIA IBARROLA-JURADO; JOSEP BASORA; RAMON ESTRUCH; MARIA ISABEL COVAS; DOLORES CORELLA; FERNANDO AROS; VALENTINA RUIZ-GUTIERREZ; EMILIO ROS; PREDIMED STUDY INVESTIGATORS
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: SALAS SALVADÓ, JORGE; BULLÓ BONET, MÒNICA; BABIO SÁNCHEZ, NANCY ELVIRA; MIGUEL ANGEL MARTINEZ-GONZALEZ; NURIA IBARROLA-JURADO; JOSEP BASORA; RAMON ESTRUCH; MARIA ISABEL COVAS; DOLORES CORELLA; FERNANDO AROS; VALENTINA RUIZ-GUTIERREZ; EMILIO ROS; PREDIMED STUDY INVESTIGATORS
    Palabras clave: Type-2 diabetes Mediterranean diet Randomized trial
    Resumen: OBJECTIVE: To test the effects of two Mediterranean diet (MedDiet) interventions versus a low-fat diet on incidence of diabetes. RESEARCH DESIGN AND METHODS: This was a three-arm randomized trial in 418 nondiabetic subjects aged 55-80 years recruited in one center (PREDIMED-Reus, northeastern Spain) of the Prevención con Dieta Mediterránea [PREDIMED] study, a large nutrition intervention trial for primary cardiovascular prevention in individuals at high cardiovascular risk. Participants were randomly assigned to education on a low-fat diet (control group) or to one of two MedDiets, supplemented with either free virgin olive oil (1 liter/week) or nuts (30 g/day). Diets were ad libitum, and no advice on physical activity was given. The main outcome was diabetes incidence diagnosed by the 2009 American Diabetes Association criteria. RESULTS: After a median follow-up of 4.0 years, diabetes incidence was 10.1% (95% CI 5.1-15.1), 11.0% (5.9-16.1), and 17.9% (11.4-24.4) in the MedDiet with olive oil group, the MedDiet with nuts group, and the control group, respectively. Multivariable adjusted hazard ratios of diabetes were 0.49 (0.25-0.97) and 0.48 (0.24-0.96) in the MedDiet supplemented with olive oil and nuts groups, respectively, compared with the control group. When the two MedDiet groups were pooled and compared with the control group, diabetes incidence was reduced by 52% (27-86). In all study arms, increased adherence to the MedDiet was inversely associated with diabetes incidence. Diabetes risk reduction occurred in the absence of significant changes in body weight or physical activity. CONCLUSIONS: MedDiets without calorie restriction seem to be effective in the prevention of diabetes in subjects at high cardiovascular risk.
    Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental
    Áreas temáticas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0149-5992
    Fecha de alta del registro: 2016-06-14
    Página final: 19
    Volumen de revista: 34
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: http://care.diabetesjournals.org/content/34/1/14
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.2337/dc10-1288
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2011
    Página inicial: 14
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Diabetis no-insulinodependent
    Dieta mediterrània
    Type-2 diabetes
    Mediterranean diet
    Randomized trial
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    0149-5992
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