Autor según el artículo: Salas-Salvadó, J.; Amor, AJ.; Serra-Mir, M.; Martínez-González, MA.; Corella, D.; Fitó, M.; Estruch, R.; Serra-Majem, L.; Arós, F.; Babio, N.; Ros, E.; Ortega, E.
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: SALAS SALVADÓ, JORGE; Amor, AJ.; Serra-Mir, M.; Martínez-González, MA.; Corella, D.; Fitó, M.; Estruch, R.; Serra-Majem, L.; Arós, F.; BABIO SÁNCHEZ, NANCY ELVIRA; Ros, E.; Ortega, E.
Palabras clave: Mediterranean diet Cardiovascular risk prediction cardiovascular disease
Resumen: Background-—The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We
assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in
participants, who were predefined as being at high-risk in the PREvencion con DIeta MEDiterranea (PREDIMED) study—a
nutrition-intervention primary prevention trial—and the impact of adherence to the Mediterranean diet on CVD across risk
categories.
Methods and Results-—In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED
participants (aged 55–74 years, 57% women; 48% with type 2 diabetes mellitus). Major CVD events, the primary PREDIMED end
point, were an aggregate of myocardial infarction, stroke, and cardiovascular death. Multivariate-adjusted Cox regression was used
to calculate hazard ratios for major CVD events and effect modification from the Mediterranean diet intervention across risk strata
(low, moderate, high, very high). The Framingham-REGICOR classification of PREDIMED participants was 25.1% low risk, 44.5%
moderate risk, and 30.4% high or very high risk. During 6-year follow-up, 188 major CVD events occurred. Hazard ratios for major
CVD events increased in parallel with estimated risk (2.68, 4.24, and 6.60 for moderate, high, and very high risk), particularly in
men (7.60, 13.16, and 15.85, respectively, versus 2.16, 2.28, and 3.51, respectively, in women). Yet among those with low or
moderate risk, 32.2% and 74.3% of major CVD events occurred in men and women, respectively. Mediterranean diet adherence
was associated with CVD risk reduction regardless of risk strata (P>0.4 for interaction).
Conclusions-—Incident CVD increased in parallel with estimated risk in the PREDIMED cohort, but most events occurred in non–
high-risk categories, particularly in women. Until predictive tools are improved, promotion of the Mediterranean diet might be
useful to reduce CVD independent of baseline risk.
Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental
Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2047-9980
Identificador del autor: 0000-0003-2700-7459 ; 0000-0003-3527-5277
Fecha de alta del registro: 2018-06-22
Volumen de revista: 6
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.ahajournals.org/doi/full/10.1161/JAHA.116.004803?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1161/JAHA.116.004803
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Article Artículo Article
Repositori URV