Autor según el artículo: Pedret, Anna; Yuste, Sílvia; Ludwig, Izíar; Rubió, Laura; Romero, Maria-Paz; Valls, Rosa-María; Solà, Rosa; Motilva, Maria-José; Macià, Alba
Departamento: Medicina i Cirurgia
Autor/es de la URV: PEDRET FIGUEROLA, ANNA; Yuste, Sílvia; Ludwig, Izíar; Rubió, Laura; Romero, Maria-Paz; VALLS ZAMORA, ROSA MARIA; SOLÀ ALBERICH, ROSA MARIA; Motilva, Maria-José; Macià, Alba
Palabras clave: anthocyanins red fleshed apple phenolic metabolites
Resumen: The aim of this study was to investigate comprehensively the metabolic pathways and human bioavailability of anthocyanins and other (poly)phenols in an apple matrix, and to elucidate potential intake biomarkers. After the acute intake of a red-fleshed apple freeze-dried snack, plasma and urine were collected and analyzed by UPLC-MS/MS. A total of 37 phase-II and microbial phenolic metabolites were detected in plasma and urine. Among these, phloretin glucuronide, cyanidin-3-O-galactoside (plasma and urine) and peonidin-3-O-galactoside (urine) were the only metabolites detected in all the volunteers and not detected at basal conditions. The maximum urine excretion was detected at 2–4 h, and the main increase in plasma of phloretin glucuronide and cyanidin-3-O-galactoside was observed at 2 h post-intake (61.0 ± 6.82 and 10.3 ± 1.50 nM, respectively). These metabolites could be selected as the best intake biomarkers of red-fleshed apple and might be useful in human intervention studies when studying its health effects.
Grupo de investigación: Unitat de Recerca de Lípids i Arteriosclerosi
Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1756-4646
Identificador del autor: 0000-0002-5327-932X; ; ; ; ; 0000-0002-3351-0942; 0000-0002-8359-235X; ;
Fecha de alta del registro: 2019-03-22
Página final: 155
Volumen de revista: 55
Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Página inicial: 146
Tipo de publicación: Article Artículo Article
Repositori URV