Autor según el artículo: Vicens, P. Ribes, D. Heredia, L. Torrente, M. Domingo, J.L.

Departamento: Ciències Mèdiques Bàsiques Psicologia

e-ISSN: 2314-6141

Autor/es de la URV: Paloma Vicens,Diana Ribes, Luis Heredia, Margarita Torrente,José L. Domingo3

Resumen: The aim of the present study was to test the effects of PNU-282987 on spatial learning and memory and hippocampal neurogenesis in both intact and chronically stressed transgenic mice. Transgenic mice with susceptibility to Alzheimer's disease (AD) under immobilization stress and not-stressed animals receiving 0 and 1 mg/kg of PNU-282987 (PNU) were evaluated in a water maze task. The effects of PNU and stress on proliferation of new cells in the hippocampus of these animals were also assessed. The latency to escape the platform was significantly higher in transgenic stressed mice compared to those in the wild stressed group, as well as in transgenic animals without PNU compared to control wild group. On retention of the task, differences emerged on stressed wild animals, PNU wild group, and stressed wild mice receiving PNU. However, no significant differences were detected on new cell proliferation. The results of the present study did not show any impact of stress in acquisition of a spatial task both in wild and transgenic mice. No clear effects of PNU on acquisition of a spatial task in transgenic mice with susceptibility to AD were detected. Although PNU and stress effects were detected on retention of the task in wild animals, no changes were noted in transgenic mice.

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 2314-6133

Página final: 8

Volumen de revista: 2013

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.hindawi.com/journals/bmri/2013/952719/

DOI del artículo: 10.1155/2013/952719

Entidad: Universitat Rovira i Virgili.

Año de publicación de la revista: 2013

Página inicial: 1