Articles producció científica> Ciències Mèdiques Bàsiques

All-cause mortality in the cohorts of the Spanish AIDS Rearch Network (RIS) compared with the general population: 1997-2010

  • Datos identificativos

    Identificador: PC:585
    Handle: http://hdl.handle.net/20.500.11797/PC585
  • Autores:

    Hernando, V.
    Alejos, B.
    Monge, S.
    Berenguer, J.
    Anta, L.
    Vinuesa, D.
    Palacios, R.
    Muga, R.
    Moreno, S.
    Jarrin, I.
    and for CoRIS cohort
  • Otros:

    Autor según el artículo: Hernando, V. Alejos, B. Monge, S. Berenguer, J. Anta, L. Vinuesa, D. Palacios, R. Muga, R. Moreno, S. Jarrin, I. and for CoRIS cohort
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Victoria Hernando, Belen Alejos, Susana Monge, Juan berenguer
    Resumen: Background Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. Methods We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. Results Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997¿2003). Conclusion Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1471-2334
    Página final: 388
    Volumen de revista: 13
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: http://www.biomedcentral.com/1471-2334/13/382
    DOI del artículo: 10.1186/1471-2334-13-382
    Entidad: Universitat Rovira i Virgili.
    Año de publicación de la revista: 2013
    Página inicial: 382