Articles producció científica> Química Analítica i Química Orgànica

Performance of zwitterionic hydrophilic interaction LC for the determination of iodinated X-ray contrast agents

  • Datos identificativos

    Identificador: PC:594
    Handle: https://hdl.handle.net/20.500.11797/PC594
    Autores:
    Pocurull, E.Fontanals, N.Borrull, F.Herrero, P.Echeverría, S.
    Resumen:
    10.1002/jssc.201300702

  • Otros:

    Autor según el artículo: Pocurull, E. Fontanals, N. Borrull, F. Herrero, P. Echeverría, S.
    Departamento: Química Analítica i Química Orgànica
    e-ISSN: 1615-9314
    Resumen: This study compares the separation performance of a group of iodinated X-ray contrast media on four different columns. The first three were two stationary phases (SPs) modified with C18 and a polar-embedded SP (polar amide group bonded to an alkyl chain), all of which worked under RP-LC mode. The fourth was a zwitterionic sulphoalkylbetaine SP, working under the hydrophilic interaction LC (HILIC) mode. After the optimisation of the different parameters, the zwitterionic column displayed the best separation, which also overcomes the problems encountered when these analytes were separated under RP-LC. Moreover, when HILIC is coupled to MS/MS, sensitivity is enhanced. However, when sewage samples were analysed by SPE followed by the optimal HILIC-MS/MS, the sensitivity of the method was affected due to the high matrix effect, which had to be solved by dilution of the extract. Finally, the method was preliminarily validated with sewage and the figures of merit were comparable to those of the SPE-RP-LC-MS/MS.
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1615-9306
    Página final: 3695
    Volumen de revista: 36
    Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entidad: Universitat Rovira i Virgili.
    Año de publicación de la revista: 2013
    Página inicial: 3688