Autor según el artículo: Espinel-Ingroff, A. Pfaller, M.A. Bustamante, B. Canton, E. Fothergill, A. Fuller, J. Gonzalez, G.M. Lass-Flörl, C. Lockhart, S.R. Martin-Mazuelos, E. Meis, J.F. Melhem, M.S.C. Ostrosky-Zeichner, L. Pelaez, T. Szeszs, M.W. St-Germain, G. Bonfietti, L.X. Guarro, J. Turnidge, J.

Departamento: Ciències Mèdiques Bàsiques

e-ISSN: 1098-6596

Autor/es de la URV: A. Espinel-Ingroff, M. A. Pfaller, B. Bustamante, E. Canton, A. Fothergill, J. Fuller, G. M. Gonzalez, C. Lass-Flörl, S. R. Lockhart, E. Martin-Mazuelos, J. F. Meis, M. S. C. Melhem, L. Ostrosky-Zeichner, T. Pelaez, M. W. Szeszs, G. St-Germain, L. X. Bonfietti, J. Guarro, J. Turnidge

Resumen: Although epidemiological cutoff values (ECVs) have been established for Candida spp. and the triazoles, they are based on MIC data from a single laboratory. We have established ECVs for eight Candida species and fluconazole, posaconazole, and voricona- zole based on wild-type (WT) MIC distributions for isolates of C. albicans ( n 11,241 isolates), C. glabrata (7,538), C. parapsi- losis (6,023), C. tropicalis (3,748), C. krusei (1,073), C. lusitaniae (574), C. guilliermondii (373), and C. dubliniensis (162). The 24-h CLSI broth microdilution MICs were collated from multiple laboratories (in Canada, Brazil, Europe, Mexico, Peru, and the United States). The ECVs for distributions originating from > 6 laboratories, which included > 95% of the modeled WT popula- tion, for fluconazole, posaconazole, and voriconazole were, respectively, 0.5, 0.06 and 0.03 g/ml for C. albicans , 0.5, 0.25, and 0.03 g/ml for C. dubliniensis , 8, 1, and 0.25 g/ml for C. glabrata , 8, 0.5, and 0.12 g/ml for C. guilliermondii , 32, 0.5, and 0.25 g/ml for C. krusei , 1, 0.06, and 0.06 g/ml for C. lusitaniae , 1, 0.25, and 0.03 g/ml for C. parapsilosis , and 1, 0.12, and 0.06 g/ml for C. tropicalis . The low number of MICs ( < 100) for other less prevalent species ( C. famata , C. kefyr , C. orthopsilo- sis , C. rugosa ) precluded ECV definition, but their MIC distributions are documented. Evaluation of our ECVs for some species/ agent combinations using published individual MICs for 136 isolates (harboring mutations in or upregulation of ERG11 , MDR1 , CDR1 ,or CDR2 ) and 64 WT isolates indicated that our ECVs may be useful in distinguishing WT from non-WT isolates.

Acceso a la licencia de uso: thttps://creativecommons.org/licenses/by/3.0/es/

Palabra clave otro idioma: voriconazole

ISSN: 0066-4804

Página final: 2012

Volumen de revista: 58

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://aac.asm.org/content/58/4/2006.long

DOI del artículo: 10.1128/AAC.02615-13

Entidad: Universitat Rovira i Virgili.

Año de publicación de la revista: 2014

Página inicial: 2006