Articles producció científica> Medicina i Cirurgia

Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challenges

  • Datos identificativos

    Identificador: imarina:2329050
    Autores:
    Hernández-Aguilera AFernández-Arroyo SCuyàs ELuciano-Mateo FCabre NCamps JLopez-Miranda JMenendez JJoven J
    Resumen:
    We live in a world fascinated by the relationship between disease and nutritional disequilibrium. The subtle and slow effects of chronic nutrient toxicity are a major public health concern. Since food is potentially important for the development of "metabolic memory", there is a need for more information on the type of nutrients causing adverse or toxic effects. We now know that metabolic alterations produced by excessive intake of some nutrients, drugs and chemicals directly impact epigenetic regulation. We envision that understanding how metabolic pathways are coordinated by environmental and genetic factors will provide novel insights for the treatment of metabolic diseases. New methods will enable the assembly and analysis of large sets of complex molecular and clinical data for understanding how inflammation and mitochondria affect bioenergetics, epigenetics and health. Collectively, the observations we highlight indicate that energy utilization and disease are intimately connected by epigenetics. The challenge is to incorporate metabolo-epigenetic data in better interpretations of disease, to expedite therapeutic targeting of key pathways linking nutritional toxicity and metabolism. An additional concern is that changes in the parental phenotype are detectable in the methylome of subsequent offspring. The effect might create a menace to future generations and preconceptional considerations. Copyright © 2016 Elsevier Ltd. All rights reserved.
  • Otros:

    Autor según el artículo: Hernández-Aguilera A; Fernández-Arroyo S; Cuyàs E; Luciano-Mateo F; Cabre N; Camps J; Lopez-Miranda J; Menendez J; Joven J
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Camps Andreu, Jorge / FERNANDEZ ARROYO, SALVADOR / Joven Maried, Jorge
    Palabras clave: Obesity Nutrient toxicity Metabolomics Epigenetics Dna methylation Diabetes nutrient toxicity metabolomics epigenetics dna methylation diabetes
    Resumen: We live in a world fascinated by the relationship between disease and nutritional disequilibrium. The subtle and slow effects of chronic nutrient toxicity are a major public health concern. Since food is potentially important for the development of "metabolic memory", there is a need for more information on the type of nutrients causing adverse or toxic effects. We now know that metabolic alterations produced by excessive intake of some nutrients, drugs and chemicals directly impact epigenetic regulation. We envision that understanding how metabolic pathways are coordinated by environmental and genetic factors will provide novel insights for the treatment of metabolic diseases. New methods will enable the assembly and analysis of large sets of complex molecular and clinical data for understanding how inflammation and mitochondria affect bioenergetics, epigenetics and health. Collectively, the observations we highlight indicate that energy utilization and disease are intimately connected by epigenetics. The challenge is to incorporate metabolo-epigenetic data in better interpretations of disease, to expedite therapeutic targeting of key pathways linking nutritional toxicity and metabolism. An additional concern is that changes in the parental phenotype are detectable in the methylome of subsequent offspring. The effect might create a menace to future generations and preconceptional considerations. Copyright © 2016 Elsevier Ltd. All rights reserved.
    Áreas temáticas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 02786915
    Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat
    Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0278691516302721
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 96 191-204
    Referencia de l'ítem segons les normes APA: Hernández-Aguilera A; Fernández-Arroyo S; Cuyàs E; Luciano-Mateo F; Cabre N; Camps J; Lopez-Miranda J; Menendez J; Joven J (2016). Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challenges. Food And Chemical Toxicology, 96(), 191-204. DOI: 10.1016/j.fct.2016.08.006
    DOI del artículo: 10.1016/j.fct.2016.08.006
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Toxicology
    Obesity
    Nutrient toxicity
    Metabolomics
    Epigenetics
    Dna methylation
    Diabetes
    nutrient toxicity
    metabolomics
    epigenetics
    dna methylation
    diabetes
    Toxicology
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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