Autor según el artículo: Berenguer J., Rivero A., Jarrín I., Núñez M.J., Vivancos M.J., Crespo M., Téllez M.J., Domingo P., Iribarren J.A., Artero A., Márquez M., Santos I., Moreno J., Montero M., González-García J., Pérez-Latorre L., Miralles P., López J.C., Parras F., Padilla B., Aldámiz T., Carrero A., Díez C., Tejerina F., Arnalich F., Arribas J.R., Bernardino J.I., Hontañón V., Martín-Carbonero M.L., Montejano R., Montes M.L., Moreno V., Pérez-Valero I., Navarro C., Valencia E., Cuenca F., Rivero-Román A., Moreno S., Moreno A., Casado J.L., Berenguer J., Rivero A., Jarrín I., Núñez M.J., Vivancos M.J., Crespo M., Téllez M.J., Domingo P., Iribarren J.A., Artero A., Márquez M., Santos I., Moreno J., Montero M., González-García J., Pérez-Latorre L., Miralles P., López J.C., Parras F., Padilla B., Aldámiz T., Carrero A., Díez C., Tejerina F., Arnalich F., Arribas J.R., Bernardino J.I., Hontañón V., Martín-Carbonero M.L., Montejano R., Montes M.L., Moreno V., Pérez-Valero I., Navarro C., Valencia E., Cuenca F., Rivero-Román A., Moreno S., Moreno A., Casado J.L., Berenguer J., Rivero A., Jarrín I., Núñez M.J., Vivancos M.J., Crespo M., Téllez M.J., Domingo P., Iribarren J.A., Artero A., Márquez M., Santos I., Moreno J., Montero M., González-García J., Pérez-Latorre L., Miralles P., López J.C., Parras F., Padilla B.
Departamento: Medicina i Cirurgia
Autor/es de la URV: SIRVENT CALVERA, JUAN JOSÉ / Vidal Marsal, Francisco
Palabras clave: Spain/epidemiology Hiv infections/epidemiology Hepatitis c/drug therapy/epidemiology Coinfection/epidemiology spain/epidemiology hiv infections/epidemiology coinfection/epidemiology
Resumen: Background. ?The purpose of this study was to assess the prevalence of anti-hepatitis C virus (HCV) antibodies (Abs) and active HCV infection in human immunodeficiency virus (HIV)-infected (HIV+) patients in Spain in 2015. This was a cross-sectional study. Methods. ?The study was performed in 41 centers in 2015. Sample size was estimated for an accuracy of 2%, the number of patients from each hospital was determined by proportional allocation, and patients were selected using simple random sampling. Results. ?The reference population was 35 791 patients, and the sample size was 1867 patients. Hepatitis C virus serostatus was known in 1843 patients (98.7%). Hepatitis C virus-Abs were detected in 695 patients (37.7%), in whom the main route of HIV acquisition was injection drug use (75.4%). Of these 695 patients, 402 had HCV RNA, 170 had had a sustained viral response (SVR) after anti-HCV therapy, and 102 cleared HCV spontaneously. Hepatitis C virus-ribonucleic acid results were unknown in 21 cases. Genotype distribution (known in 367 patients) was 1a in 143 patients (39.0%), 4 in 90 (24.5%) patients, 1b in 69 (18.8%) patients, 3 in 57 (15.5%) patients, 2 in 5 (1.4%) patients, and mixed in 3 (0.8%) patients. Liver cirrhosis was present in 93 patients (23.1%) with active HCV infection and in 39 (22.9%) patients with SVR after anti-HCV therapy. Conclusions. ?The prevalence of HCV-Abs and active HCV infection in HIV+ patients in Spain is 37.7% and 22.1%, respectively; these figures are significantly lower than those recorded in 2002 and 2009. The predominant genotypes in patients with active HCV infection were 1a and 4. A high percentage of patients had cirrhosis. Cirrhosis is also common in patients with SVR after anti-HCV therapy.
Áreas temáticas: Saúde coletiva Oncology Neurology (clinical) Microbiology Medicina ii Medicina i Infectious diseases Immunology Ciências biológicas i
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 23288957
Direcció de correo del autor: francesc.vidal@urv.cat
Identificador del autor: 0000-0002-6692-6186
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://academic.oup.com/ofid/article/3/2/ofw059/2399307
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Open Forum Infectious Diseases. 3 (2): ofw059-
Referencia de l'ítem segons les normes APA: Berenguer J., Rivero A., Jarrín I., Núñez M.J., Vivancos M.J., Crespo M., Téllez M.J., Domingo P., Iribarren J.A., Artero A., Márquez M., Santos I., M (2016). Human immunodeficiency virus/hepatitis C virus coinfection in Spain: Prevalence and patient characteristics. Open Forum Infectious Diseases, 3(2), ofw059-. DOI: 10.1093/ofid/ofw059
DOI del artículo: 10.1093/ofid/ofw059
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Tipo de publicación: Journal Publications